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Tbio
AKAP4
A-kinase anchor protein 4

Protein Summary
Description
Major structural component of sperm fibrous sheath. Plays a role in sperm motility. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358526
  • ENSP00000351327
  • ENSG00000147081
  • ENST00000376064
  • ENSP00000365232

Symbol
  • AKAP82
  • HI
  • p82
  • CT99
  • FSC1
  • PRKA4
  • AKAP-4
  • AKAP82
  • AKAP 82
  • hAKAP82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.82
cell type or tissue
0.67
kinase perturbation
0.6
gene perturbation
0.59
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.49   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.49   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
PRKAR2A
Tchem
Family:  Enzyme
Novelty:  0.06183318
Score:  0.955
Data Source:  STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
Score:  0.905
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.901
Data Source:  STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.901
Data Source:  STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
Score:  0.86
Data Source:  STRINGDB
FSIP1
Tbio
Novelty:  0.02610106
Score:  0.818
Data Source:  STRINGDB
FSIP2
Tdark
Novelty:  0.16245939
Score:  0.803
Data Source:  STRINGDB
CCNB3
Tbio
Novelty:  0.01885821
Score:  0.8
Data Source:  STRINGDB
TEX13A
Tdark
Novelty:  1.13928013
Score:  0.758
Data Source:  STRINGDB
TSN
Tbio
Novelty:  0.00510474
Score:  0.751
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
A-kinase anchoring protein 4
694888
Mouse
MGI:102794
11643
Rat
RGD:620828
79254
Dog
A-kinase anchoring protein 4
VGNC:37757
480917
Horse
A-kinase anchoring protein 4
VGNC:15203
100052348
Species
Name
OMA
EggNOG
Inparanoid
Macaque
A-kinase anchoring protein 4
Mouse
Rat
Dog
A-kinase anchoring protein 4
Horse
A-kinase anchoring protein 4
Publication Statistics
PubMed Score 142.49
PubMed score by year
PubTator Score 55.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title