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Tbio
AKAP3
A-kinase anchor protein 3

Protein Summary
Description
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228850
  • ENSP00000228850
  • ENSG00000111254
  • ENST00000545990
  • ENSP00000440994

Symbol
  • AKAP110
  • SOB1
  • CT82
  • SOB1
  • FSP95
  • PRKA3
  • HEL159
  • AKAP110
  • AKAP 110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
tissue sample
0.69
cell type or tissue
0.63
virus perturbation
0.59
cell line
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.579
Data Source:  BioPlex,STRINGDB
ROPN1L
Tbio
Novelty:  0.18077695
Score:  0.946
Data Source:  STRINGDB
ROPN1
Tbio
Novelty:  0.05375245
Score:  0.943
Data Source:  STRINGDB
CABYR
Tbio
Novelty:  0.0414671
Score:  0.894
Data Source:  STRINGDB
SPA17
Tbio
Novelty:  0.02632554
Score:  0.876
Data Source:  STRINGDB
CCDC54
Tbio
Novelty:  0.02413126
Score:  0.759
Data Source:  STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
Score:  0.72
Data Source:  STRINGDB
FSIP2
Tdark
Novelty:  0.16245939
Score:  0.663
Data Source:  STRINGDB
FSIP1
Tbio
Novelty:  0.02610106
Score:  0.66
Data Source:  STRINGDB
NDUFAF3
Tclin
Family:  Enzyme
Novelty:  0.00063584
Score:  0.64
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (58)
Find Similar Targets
Items per page:
1 – 5 of 58
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
G Protein Signaling Pathways
WikiPathways
Differentiation Pathway
WikiPathways
Differentiation Pathway
WikiPathways
Differentiation Pathway
WikiPathways
Differentiation Pathway
Name
Explore in Pharos
Explore in Source
G Protein Signaling Pathways
Differentiation Pathway
Differentiation Pathway
Differentiation Pathway
Differentiation Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
16.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 3
VGNC:4916
466927
Macaque
A-kinase anchoring protein 3
711162
Mouse
MGI:1341149
11642
Rat
RGD:1359735
312720
Dog
A-kinase anchoring protein 3
VGNC:37756
477719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 3
Macaque
A-kinase anchoring protein 3
Mouse
Rat
Dog
A-kinase anchoring protein 3
Publication Statistics
PubMed Score 44.88
PubMed score by year
PubTator Score 22.73
PubTator score by year
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Related Publications
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PMID
Year
Title