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Tbio
AKAP17A
A-kinase anchor protein 17A

Protein Summary
Description
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313871
  • ENSP00000324827
  • ENSG00000197976
  • ENST00000474361
  • ENSP00000435479

Symbol
  • CXYorf3
  • DXYS155E
  • SFRS17A
  • XE7
  • XE7
  • 721P
  • XE7Y
  • CCDC133
  • CXYorf3
  • PRKA17A
  • SFRS17A
  • AKAP-17A
  • DXYS155E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
tissue sample
0.7
cellular component
0.67
kinase perturbation
0.6
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  1
Data Source:  BioPlex
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.999998985
p_ni:  0.000001015
Score:  0.187
Data Source:  BioPlex,STRINGDB
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999978786
p_ni:  0.000021192
p_wrong:  2.2e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.999897846
p_ni:  0.000102154
Score:  0.356
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.999635665
p_ni:  0.000291924
p_wrong:  0.000072412
Score:  0.167
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999516462
p_ni:  0.000318693
p_wrong:  0.000164845
Score:  0.173
Data Source:  BioPlex,STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.99630114
p_ni:  0.00369886
Score:  0.155
Data Source:  BioPlex,STRINGDB
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.991940238
p_ni:  0.008059761
p_wrong:  1e-9
Data Source:  BioPlex
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.978481822
p_ni:  0.021518178
Score:  0.166
Data Source:  BioPlex,STRINGDB
CAAP1
Tbio
Family:  Enzyme
Novelty:  0.01569048
p_int:  0.967505368
p_ni:  0.032494632
Score:  0.825
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
6.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
A-kinase anchoring protein 17A
693468
Rat
RGD:1564640
288526
Horse
A-kinase anchoring protein 17A
VGNC:49350
100069806
Opossum
A-kinase anchoring protein 17A
100010187
Chicken
A-kinase anchoring protein 17A
CGNC:12506
418664
Species
Name
OMA
EggNOG
Inparanoid
Macaque
A-kinase anchoring protein 17A
Rat
Horse
A-kinase anchoring protein 17A
Opossum
A-kinase anchoring protein 17A
Chicken
A-kinase anchoring protein 17A
Publication Statistics
PubMed Score 31.76
PubMed score by year
PubTator Score 8.00
PubTator score by year
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Related Publications
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PMID
Year
Title