You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AKAP14
A-kinase anchor protein 14

Protein Summary
Description
Binds to type II regulatory subunits of protein kinase A and anchors/targets them. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334356
  • ENSP00000334680
  • ENSG00000186471
  • ENST00000371422
  • ENSP00000360476
  • ENST00000371425
  • ENSP00000360479
  • ENST00000371431
  • ENSP00000360485

Symbol
  • AKAP28
  • AKAP28
  • PRKA14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
virus perturbation
0.59
PubMedID
0.57
disease perturbation
0.49
tissue
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999999798
p_ni:  2.02e-7
Score:  0.807
Data Source:  BioPlex,STRINGDB
SPA17
Tbio
Novelty:  0.02632554
p_int:  0.999999353
p_ni:  6e-9
p_wrong:  6.41e-7
Score:  0.896
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.999980368
p_ni:  0.000019631
p_wrong:  1e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  0.99996722
p_ni:  0.000032778
p_wrong:  3e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
p_int:  0.996585789
p_ni:  0.003414211
Score:  0.962
Data Source:  BioPlex,STRINGDB
PRKAR2A
Tchem
Family:  Enzyme
Novelty:  0.06183318
p_int:  0.991103992
p_ni:  0.008896008
Score:  0.952
Data Source:  BioPlex,STRINGDB
OCIAD1
Tbio
Novelty:  0.05701069
p_int:  0.951892337
p_ni:  0.048107662
Score:  0.157
Data Source:  BioPlex,STRINGDB
SYNJ2BP
Tbio
Novelty:  0.02520087
p_int:  0.94258671
p_ni:  0.05741329
Score:  0.527
Data Source:  BioPlex,STRINGDB
EFCAB7
Tdark
Novelty:  0.36952617
p_int:  0.93824093
p_ni:  0.000440484
p_wrong:  0.061318585
Score:  0.737
Data Source:  BioPlex,STRINGDB
ARL5B
Tbio
Family:  Enzyme
Novelty:  0.03703395
p_int:  0.882648077
p_ni:  0.091357511
p_wrong:  0.025994412
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 14
VGNC:2732
736819
Macaque
A-kinase anchoring protein 14
694769
Horse
A-kinase anchoring protein 14
VGNC:51917
100629400
Cow
A-kinase anchoring protein 14
VGNC:25783
100296237
Platypus
A-kinase anchoring protein 14
103170660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 14
Macaque
A-kinase anchoring protein 14
Horse
A-kinase anchoring protein 14
Cow
A-kinase anchoring protein 14
Platypus
A-kinase anchoring protein 14
Publication Statistics
PubMed Score 2.13
PubMed score by year
PubTator Score 1.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title