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Tbio
AKAP11
A-kinase anchor protein 11

Protein Summary
Description
Binds to type II regulatory subunits of protein kinase A and anchors/targets them. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000025301
  • ENSP00000025301
  • ENSG00000023516

Symbol
  • AKAP220
  • KIAA0629
  • PRKA11
  • AKAP-11
  • AKAP220
  • PPP1R44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.9
virus perturbation
0.83
histone modification site profile
0.72
disease perturbation
0.62
cell type or tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.999998035
p_ni:  0.000001965
Score:  0.706
Data Source:  BioPlex,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999993656
p_ni:  0.000006344
Score:  0.551
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999979568
p_ni:  0.000020432
Score:  0.198
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999973312
p_ni:  0.000026688
Score:  0.187
Data Source:  BioPlex,STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.999585479
p_ni:  0.000414521
Score:  0.772
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.997009013
p_ni:  0.002990987
Data Source:  BioPlex
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.995934391
p_ni:  0.004065609
Data Source:  BioPlex
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.992129334
p_ni:  0.007870666
Data Source:  BioPlex
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.985520566
p_ni:  0.014479434
Data Source:  BioPlex
DCLRE1C
Tbio
Novelty:  0.01064408
p_int:  0.982780839
p_ni:  0.017219161
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (87)
Find Similar Targets
Items per page:
1 – 5 of 87
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
Name
Explore in Pharos
Explore in Source
G Protein Signaling Pathways
G Protein Signaling Pathways
G Protein Signaling Pathways
G Protein Signaling Pathways
G Protein Signaling Pathways
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
9
6
11
1.2
98.4
heel bone mineral density
3
3
7
97.8
alkaline phosphatase measurement
3
3
2
16.5
97.8
lymphocyte count
2
2
2
89.4
2
2
0
1.1
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
11
1.2
98.4
heel bone mineral density
7
97.8
alkaline phosphatase measurement
2
16.5
97.8
lymphocyte count
2
89.4
0
1.1
88.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 11
VGNC:5041
740874
Macaque
A-kinase anchoring protein 11
702787
Mouse
MGI:2684060
219181
Rat
RGD:2079
498549
Dog
A-kinase anchoring protein 11
VGNC:37753
609431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 11
Macaque
A-kinase anchoring protein 11
Mouse
Rat
Dog
A-kinase anchoring protein 11
Publication Statistics
PubMed Score 15.43
PubMed score by year
PubTator Score 12.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title