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Tbio
AKAP1
A-kinase anchor protein 1, mitochondrial

Protein Summary
Description
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314126
  • ENSP00000314075
  • ENSG00000121057
  • ENST00000337714
  • ENSP00000337736
  • ENST00000481416
  • ENSP00000433212
  • ENST00000539273
  • ENSP00000443139
  • ENST00000571629
  • ENSP00000459968
  • ENST00000572557
  • ENSP00000459895
  • ENST00000621116
  • ENSP00000478212

Symbol
  • AKAP149
  • PRKA1
  • AKAP
  • PRKA1
  • AKAP84
  • TDRD17
  • AKAP121
  • AKAP149
  • D-AKAP1
  • PPP1R43
  • SAKAP84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.93
transcription factor perturbation
0.91
PubMedID
0.81
cellular component
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.88   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.88   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0