Tbio AK6 Adenylate kinase isoenzyme 6

Protein Summary

Description

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q9Y3D8
• A8MSZ6
• Q5F2S9
• AK6

Gene Name

• AK6

Ensembl ID

• ENST00000380818
• ENSP00000370197
• ENSG00000085231
• ENST00000380822
• ENSP00000370201
• ENST00000612207
• ENSP00000484679
• ENSG00000279247
• ENST00000620269
• ENSP00000480829

Symbol

• CINAP
• CIP
• CINAP
• AD-004
• hCINAP
• CGI-137

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
disease	0.75
tissue	0.61
cellular component	0.58
biological term	0.33

Protein Classes

DTO Classes

Protein / Kinase / Unclassified Protein / Adenylate Kinase Isoenzyme 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.51   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.51   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (206)

Explore Interacting Targets

1 – 10 of 206

• See Interactions on String-DB

TAF8

Tbio

Novelty:  0.01056638

p_int:  0.999998949

p_ni:  0.000001051

Score:  0.981

Data Source:  BioPlex,STRINGDB

TAF7L

Tbio

Novelty:  0.08132691

p_int:  0.999998282

p_ni:  0.000001717

Score:  0.782

Data Source:  BioPlex,STRINGDB

TFEB

Tbio

Family:  TF

Novelty:  0.00248413

p_int:  0.999939829

p_ni:  0.000060171

Score:  0.189

Data Source:  BioPlex,STRINGDB

TADA2B

Tbio

Family:  TF

Novelty:  0.06387677

p_int:  0.999898139

p_ni:  0.00010186

Score:  0.909

Data Source:  BioPlex,STRINGDB

RPS14

Tbio

Novelty:  0.00576737

p_int:  0.999833308

p_ni:  0.000166692

Score:  0.979

Data Source:  BioPlex,STRINGDB

TAF6L

Tdark

Family:  Enzyme

Novelty:  0.7411477

p_int:  0.999803749

p_ni:  0.000196251

Score:  0.972

Data Source:  BioPlex,STRINGDB

TADA1

Tdark

Novelty:  0.09903801

p_int:  0.999598968

p_ni:  0.000401032

Score:  0.972

Data Source:  BioPlex,STRINGDB

ATXN7L3

Tbio

Novelty:  0.1572083

p_int:  0.99624812

p_ni:  0.003751878

p_wrong:  2e-9

Score:  0.966

Data Source:  BioPlex,STRINGDB

TRPC5

Tchem

Family:  IC

Novelty:  0.00406517

p_int:  0.965686066

p_ni:  0.034313934

Score:  0.282

Data Source:  BioPlex,STRINGDB

MYCL

Tbio

Family:  TF

Novelty:  0.0034508

p_int:  0.803110684

p_ni:  0.196872706

p_wrong:  0.00001661

Data Source:  BioPlex

Nearest Tclin Targets (19)

Explore Nearest Tclin Targets

Upstream (10)

Downstream (9)

1 – 5 of 10

PDE8A

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE7B

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE4D

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

RRM1

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE4A

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

Pathways (6)

Reactome (3)

KEGG (3)

Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Interconversion of nucleotide di- and triphosphates	30 targets	R-HSA-499943
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869

Name	Explore in Pharos	Explore in Source
Interconversion of nucleotide di- and triphosphates	30 targets	R-HSA-499943
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (4)

Components (6)

Processes (1)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
adenylate kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleoside monophosphate kinase activity	Traceable Author Statement (TAS)	Reactome
ATPase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule

Disease Associations (null)

No disease associations found

GWAS Traits (28)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	ENSG00000085231	3	3	3		94.3
neutrophil count	EFO_0004833	ENSG00000279247	3	3	3		94.3
myeloid white cell count	EFO_0007988	ENSG00000085231	2	2	2		90.1
myeloid white cell count	EFO_0007988	ENSG00000279247	2	2	2		90.1
leukocyte count	EFO_0004308	ENSG00000085231	2	2	2		86.1

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	3		94.3
neutrophil count	EFO_0004833	3		94.3
myeloid white cell count	EFO_0007988	2		90.1
myeloid white cell count	EFO_0007988	2		90.1
leukocyte count	EFO_0004308	2		86.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Nucleus
Reference proteome
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
blood urea nitrogen measurement
glomerular filtration rate
granulocyte count
granulocyte percentage of myeloid white cells
interleukin 18 measurement
leukocyte count
lymphocyte percentage of leukocytes
monocyte percentage of leukocytes
myeloid white cell count
neutrophil count

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 11.51

PubMed score by year

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PubTator Score 27.29

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (3)

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PMID	Year	Title