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Tbio
AK4
Adenylate kinase 4, mitochondrial

Protein Summary
Description
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and N ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327299
  • ENSP00000322175
  • ENSG00000162433
  • ENST00000395334
  • ENSP00000378743
  • ENST00000545314
  • ENSP00000445912

Symbol
  • AK3
  • AK3L1
  • AK3
  • AK 4
  • AK3L1
  • AK3L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.95
gene perturbation
0.95
small molecule perturbation
0.95
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.994681482
p_ni:  0.005318512
p_wrong:  6e-9
Data Source:  BioPlex
TFAP2B
Tbio
Family:  TF
Novelty:  0.01383202
p_int:  0.991602769
p_ni:  0.006019137
p_wrong:  0.002378094
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.981286088
p_ni:  0.01871377
p_wrong:  1.43e-7
Data Source:  BioPlex
ATF6B
Tbio
Family:  TF
Novelty:  0.07061573
p_int:  0.97925853
p_ni:  0.020741469
p_wrong:  1e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
NSDHL
Tbio
Family:  Enzyme
Novelty:  0.01651408
p_int:  0.95950034
p_ni:  0.040498004
p_wrong:  0.000001656
Data Source:  BioPlex
CXCL14
Tbio
Novelty:  0.00606628
p_int:  0.958984514
p_ni:  0.036980366
p_wrong:  0.00403512
Data Source:  BioPlex
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.958741923
p_ni:  0.041256557
p_wrong:  0.00000152
Score:  0.183
Data Source:  BioPlex,STRINGDB
CCL5
Tchem
Novelty:  0.00032607
p_int:  0.951429026
p_ni:  0.048570782
p_wrong:  1.92e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
ZMYM6
Tbio
Novelty:  0.4933879
p_int:  0.895987479
p_ni:  0.104003954
p_wrong:  0.000008566
Data Source:  BioPlex
TNRC6A
Tbio
Novelty:  0.00505282
p_int:  0.895987479
p_ni:  0.104003954
p_wrong:  0.000008566
Data Source:  BioPlex
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
1 – 5 of 10
PDE4B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE8A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE7B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
RRM1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (9)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
5
5
94.1
acetone measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
94.1
acetone measurement
1
12.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 4
VGNC:10539
450169
Mouse
MGI:87979
11639
Rat
RGD:2078
29223
Horse
adenylate kinase 4
VGNC:15197
100069665
Cow
adenylate kinase 4
VGNC:25773
517063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 4
Mouse
Rat
Horse
adenylate kinase 4
Cow
adenylate kinase 4
Publication Statistics
PubMed Score 123.89
PubMed score by year
PubTator Score 17.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title