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Tbio
AK3
GTP:AMP phosphotransferase AK3, mitochondrial

Protein Summary
Description
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359883
  • ENSP00000352948
  • ENSG00000147853
  • ENST00000381809
  • ENSP00000371230
  • ENST00000447596
  • ENSP00000413933
  • ENST00000611749
  • ENSP00000482308

Symbol
  • AK3L1
  • AK6
  • AKL3L
  • AK6
  • FIX
  • AK3L1
  • AKL3L
  • AKL3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.88
small molecule perturbation
0.87
PubMedID
0.86
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.41   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.41   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
HNRNPUL2
Tbio
Novelty:  0.2133502
Score:  0.976
Data Source:  STRINGDB
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
Score:  0.974
Data Source:  STRINGDB
NT5M
Tchem
Family:  Enzyme
Novelty:  0.03299091
Score:  0.969
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.961
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.946
Data Source:  STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
Score:  0.945
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.942
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.941
Data Source:  STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
Score:  0.934
Data Source:  STRINGDB
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 17
RRM1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
PDE8A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
PDE7A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
Pathways (5)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
14
11
16
5
99.9
platelet crit
2
7
10
92.2
liver fibrosis measurement
3
2
6
87
neutrophil count
4
3
6
82.4
IGF-1 measurement
1
1
1
71.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
16
5
99.9
platelet crit
10
92.2
liver fibrosis measurement
6
87
neutrophil count
6
82.4
IGF-1 measurement
1
71.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 3
VGNC:4605
464977
Macaque
adenylate kinase 3
694714
Mouse
MGI:1860835
56248
Rat
RGD:619885
26956
Dog
GTP:AMP phosphotransferase AK3, mitochondrial
480491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 3
Macaque
adenylate kinase 3
Mouse
Rat
Dog
GTP:AMP phosphotransferase AK3, mitochondrial
Publication Statistics
PubMed Score 42.41
PubMed score by year
PubTator Score 101.06
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title