AIRE
Autoimmune regulator
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
hub protein | 0.95 | ||
molecular function | 0.9 | ||
tissue | 0.67 | ||
gene perturbation | 0.66 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Ubiquitin mediated proteolysis | ||||
KEGG | Primary immunodeficiency | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Ubiquitin mediated proteolysis | ||||
Primary immunodeficiency | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Inferred by Curator (IC) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 1.1 | 90.1 | |||||
Addison disease | 1 | 2 | 0 | 2.8 | 88.2 | ||||
eosinophil count | 3 | 2 | 3 | 85.1 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 82.2 | |||||
1 | 1 | 0 | 1.1 | 77.7 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 90.1 | |||||
Addison disease | 0 | 2.8 | 88.2 | ||||
eosinophil count | 3 | 85.1 | |||||
eosinophil percentage of leukocytes | 2 | 82.2 | |||||
0 | 1.1 | 77.7 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | autoimmune regulator | VGNC:1159 | 474134 | |||||
Macaque | autoimmune regulator | 712858 | ||||||
Mouse | MGI:1338803 | 11634 | ||||||
Rat | RGD:1311139 | 294328 | ||||||
Dog | autoimmune regulator | VGNC:37743 | 487796 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | autoimmune regulator | |||||
Macaque | autoimmune regulator | |||||
Mouse | ||||||
Rat | ||||||
Dog | autoimmune regulator | |||||
PMID | Year | Title |
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