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Tbio
AIRE
Autoimmune regulator

Protein Summary
Description
Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291582
  • ENSP00000291582
  • ENSG00000160224

Symbol
  • APECED
  • APS1
  • APSI
  • PGA1
  • AIRE1
  • APECED
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
hub protein
0.95
molecular function
0.9
tissue
0.67
gene perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 723.18   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 723.18   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
p_int:  0.999926607
p_ni:  0.000060896
p_wrong:  0.000012497
Data Source:  BioPlex
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.99865544
p_ni:  0.001314273
p_wrong:  0.000030286
Data Source:  BioPlex
GDPD3
Tbio
Family:  Enzyme
Novelty:  0.18121762
p_int:  0.998240073
p_ni:  0.001046736
p_wrong:  0.00071319
Score:  0.194
Data Source:  BioPlex,STRINGDB
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.997741797
p_ni:  0.002255984
p_wrong:  0.000002219
Score:  0.214
Data Source:  BioPlex,STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
p_int:  0.993976332
p_ni:  0.005669299
p_wrong:  0.000354369
Data Source:  BioPlex
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
p_int:  0.991349017
p_ni:  0.008650732
p_wrong:  2.52e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.989757993
p_ni:  0.010242007
Data Source:  BioPlex
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
p_int:  0.986807517
p_ni:  0.013192482
p_wrong:  1e-9
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.938336342
p_ni:  0.051413777
p_wrong:  0.010249882
Data Source:  BioPlex
ALOX12B
Tbio
Family:  Enzyme
Novelty:  0.02778552
p_int:  0.918632508
p_ni:  0.081367491
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
90.1
Addison disease
1
2
0
2.8
88.2
eosinophil count
3
2
3
85.1
eosinophil percentage of leukocytes
2
2
2
82.2
1
1
0
1.1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.1
Addison disease
0
2.8
88.2
eosinophil count
3
85.1
eosinophil percentage of leukocytes
2
82.2
0
1.1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autoimmune regulator
VGNC:1159
474134
Macaque
autoimmune regulator
712858
Mouse
MGI:1338803
11634
Rat
RGD:1311139
294328
Dog
autoimmune regulator
VGNC:37743
487796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autoimmune regulator
Macaque
autoimmune regulator
Mouse
Rat
Dog
autoimmune regulator
Publication Statistics
PubMed Score 723.18
PubMed score by year
PubTator Score 725.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title