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Tchem
AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Protein Summary
Description
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223029
  • ENSP00000223029
  • ENSG00000106305
  • ENST00000395236
  • ENSP00000378658

Symbol
  • JTV1
  • P38
  • JTV1
  • HLD17
  • JTV-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.96
kinase perturbation
0.96
interacting protein
0.92
histone modification site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.09   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.09   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (110)
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.999982175
p_ni:  0.000017825
Score:  0.999
Data Source:  BioPlex,STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.999495173
p_ni:  0.000504827
Score:  0.999
Data Source:  BioPlex,STRINGDB
SDCBP
Tchem
Novelty:  0.00242211
p_int:  0.997768809
p_ni:  0.002231191
Score:  0.815
Data Source:  BioPlex,STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
p_int:  0.995715384
p_ni:  0.004284616
Score:  0.997
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.956585935
p_ni:  0.043414065
Score:  0.998
Data Source:  BioPlex,STRINGDB
EEF1E1
Tbio
Novelty:  0.06216577
Score:  0.999
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.999
Data Source:  STRINGDB
MARS
Tchem
Family:  Enzyme
Novelty:  0.01318702
Score:  0.998
Data Source:  STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
Score:  0.996
Data Source:  STRINGDB
DARS
Tbio
Family:  Enzyme
Novelty:  0.01101888
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (140)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
5
5
89.7
reticulocyte measurement
3
4
5
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
89.7
reticulocyte measurement
5
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
VGNC:13627
741505
Macaque
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
717612
Mouse
MGI:2385237
231872
Rat
RGD:1560787
288480
Dog
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
479752
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Macaque
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Mouse
Rat
Dog
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Publication Statistics
PubMed Score 51.09
PubMed score by year
PubTator Score 37.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title