Tbio AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Protein Summary

Description

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q12904
• B3KTR2
• B4E1S7
• Q6FG28
• Q96CQ9

Gene Name

• AIMP1

Ensembl ID

• ENST00000358008
• ENSP00000350699
• ENSG00000164022
• ENST00000394701
• ENSP00000378191
• ENST00000442366
• ENSP00000405248

Symbol

• EMAP2
• SCYE1
• p43
• HLD3
• EMAP2
• SCYE1
• EMAPII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.88
virus perturbation	0.85
disease perturbation	0.83
transcription factor binding site profile	0.69

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Aminoacyl Trna Synthase Complex-interacting Multifunctional Protein 1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Aminoacyl Trna Synthase Complex-interacting Multifunctional Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.61   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 540   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.61   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0