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Tbio
AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Protein Summary
Description
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358008
  • ENSP00000350699
  • ENSG00000164022
  • ENST00000394701
  • ENSP00000378191
  • ENST00000442366
  • ENSP00000405248

Symbol
  • EMAP2
  • SCYE1
  • p43
  • HLD3
  • EMAP2
  • SCYE1
  • EMAPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.88
virus perturbation
0.85
disease perturbation
0.83
transcription factor binding site profile
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.61   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 540   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.61   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 540   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (199)
OPTN
Tbio
Novelty:  0.00080427
p_int:  0.999997342
p_ni:  0.000002658
Score:  0.19
Data Source:  BioPlex,STRINGDB
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.999994292
p_ni:  0.000005708
Score:  0.931
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.999993409
p_ni:  0.000006591
Score:  0.999
Data Source:  BioPlex,STRINGDB
SDCBP
Tchem
Novelty:  0.00242211
p_int:  0.999764334
p_ni:  0.000235666
Score:  0.828
Data Source:  BioPlex,STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.9996742
p_ni:  0.0003258
Score:  0.998
Data Source:  BioPlex,STRINGDB
AIMP2
Tchem
Family:  Enzyme
Novelty:  0.03283387
p_int:  0.999495173
p_ni:  0.000504827
Score:  0.999
Data Source:  BioPlex,STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
p_int:  0.999301177
p_ni:  0.000698823
Score:  0.998
Data Source:  BioPlex,STRINGDB
EEF1E1
Tbio
Novelty:  0.06216577
p_int:  0.998215101
p_ni:  0.001784899
Score:  0.999
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.99715385
p_ni:  0.00284615
Score:  0.998
Data Source:  BioPlex,STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
p_int:  0.996684787
p_ni:  0.003315213
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
65.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
VGNC:10380
461421
Macaque
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
695147
Mouse
MGI:102774
13722
Rat
RGD:620466
114632
Dog
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
487893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Macaque
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Mouse
Rat
Dog
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Publication Statistics
PubMed Score 177.61
PubMed score by year
PubTator Score 164.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title