AIFM2
Apoptosis-inducing factor 2
Protein Summary
Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
- ENST00000307864
- ENSP00000312370
- ENSG00000042286
- ENST00000373248
- ENSP00000362345
- ENST00000613322
- ENSP00000478931
- AMID
- PRG3
- AMID
- PRG3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.81 | ||
cell type or tissue | 0.74 | ||
histone modification site profile | 0.73 | ||
cellular component | 0.68 | ||
tissue sample | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.04 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 267 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.04 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 267 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (39)
DHRS4
Family: Enzyme
Novelty: 0.02992279
p_int: 0.998185225
p_ni: 0.001814775
Data Source: BioPlex
C2CD5
Novelty: 0.40144687
p_int: 0.976988537
p_ni: 0.023004382
p_wrong: 0.000007081
Data Source: BioPlex
PPP2CA
Family: Enzyme
Novelty: 0.00496839
p_int: 0.962711788
p_ni: 0.037288212
Data Source: BioPlex
ECHDC1
Family: Enzyme
Novelty: 0.02711265
p_int: 0.959290695
p_ni: 0.040709305
Data Source: BioPlex
SESTD1
Novelty: 0.2052002
p_int: 0.94804698
p_ni: 0.04409813
p_wrong: 0.00785489
Data Source: BioPlex
PPP2R2D
Family: Enzyme
Novelty: 0.0658328
p_int: 0.902698174
p_ni: 0.097301826
Data Source: BioPlex
Nearest Tclin Targets
Pathways (81)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (73)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | TP53 Regulates Transcription of Cell Death Genes | ||||
Reactome | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
TP53 Regulates Transcription of Cell Death Genes | ||||
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (7)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 38.8 | |||||
eyelid sagging measurement | 1 | 1 | 0 | 4 | 33.1 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 1 | 38.8 | |||||
eyelid sagging measurement | 0 | 4 | 33.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | apoptosis inducing factor, mitochondria associated 2 | 711037 | ||||||
Mouse | MGI:1918611 | 71361 | ||||||
Rat | RGD:1304964 | 361843 | ||||||
Dog | apoptosis inducing factor, mitochondria associated 2 | VGNC:37738 | 479236 | |||||
Horse | apoptosis inducing factor, mitochondria associated 2 | VGNC:15187 | 100063387 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | apoptosis inducing factor, mitochondria associated 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | apoptosis inducing factor, mitochondria associated 2 | |||||
Horse | apoptosis inducing factor, mitochondria associated 2 | |||||
Publication Statistics
PubMed Score 33.04
PubMed score by year
PubTator Score 13.03
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
|---|