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Tbio
AIFM1
Apoptosis-inducing factor 1, mitochondrial

Protein Summary
Description
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the transl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287295
  • ENSP00000287295
  • ENSG00000156709
  • ENST00000319908
  • ENSP00000315122
  • ENST00000346424
  • ENSP00000316320
  • ENST00000416073
  • ENSP00000402535
  • ENST00000535724
  • ENSP00000446113

Symbol
  • AIF
  • PDCD8
  • AIF
  • CMT2D
  • CMTX4
  • COWCK
  • DFNX5
  • NADMR
  • NAMSD
  • PDCD8
  • COXPD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
interacting protein
1
hub protein
0.92
protein domain
0.85
disease
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.83   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 782   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.83   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 782   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0