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Tbio
AIF1
Allograft inflammatory factor 1

Protein Summary
Description
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376049
  • ENSP00000365217
  • ENSG00000204472
  • ENST00000376059
  • ENSP00000365227
  • ENST00000383473
  • ENSP00000372965
  • ENSG00000206428
  • ENST00000383474
  • ENSP00000372966
  • ENST00000413349
  • ENSP00000416061
  • ENSG00000235985
  • ENST00000414149
  • ENSP00000391720
  • ENSG00000237727
  • ENST00000415830
  • ENSP00000413709
  • ENST00000416422
  • ENSP00000399901
  • ENSG00000234836
  • ENST00000419376
  • ENSP00000401433
  • ENST00000424944
  • ENSP00000399621
  • ENSG00000235588
  • ENST00000425748
  • ENSP00000398013
  • ENST00000440907
  • ENSP00000397842

Symbol
  • G1
  • IBA1
  • IBA1
  • IRT1
  • AIF-1
  • IRT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.91
gene perturbation
0.85
disease
0.79
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2906.16   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 765   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2906.16   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 765   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
GFAP
Tbio
Novelty:  0.00020932
Score:  0.92
Data Source:  STRINGDB
RBFOX3
Tbio
Novelty:  0.00038317
Score:  0.894
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.82
Data Source:  STRINGDB
CD68
Tbio
Novelty:  0.00017859
Score:  0.8
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.78
Data Source:  STRINGDB
LCP1
Tbio
Novelty:  0.0035357
Score:  0.765
Data Source:  STRINGDB
CX3CR1
Tchem
Family:  GPCR
Novelty:  0.00114874
Score:  0.759
Data Source:  STRINGDB
GAPDH
Tchem
Family:  Enzyme
Novelty:  0.00005849
Score:  0.745
Data Source:  STRINGDB
MBP
Tbio
Novelty:  0.00016333
Score:  0.742
Data Source:  STRINGDB
MRC1
Tbio
Novelty:  0.00104675
Score:  0.73
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (49)
Find Similar Targets
Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Spinal Cord Injury
WikiPathways
Spinal Cord Injury
WikiPathways
Copper homeostasis
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
miRNAs involved in DNA damage response
Name
Explore in Pharos
Explore in Source
Spinal Cord Injury
Spinal Cord Injury
Copper homeostasis
Integrated Breast Cancer Pathway
miRNAs involved in DNA damage response
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (600)
Items per page:
1 – 5 of 600
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
Items per page:
1 – 5 of 600
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1343098
11629
Rat
RGD:61924
29427
Dog
allograft inflammatory factor 1
VGNC:37735
474841
Horse
allograft inflammatory factor 1
VGNC:15185
100050158
Cow
allograft inflammatory factor 1
VGNC:25759
280989
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
allograft inflammatory factor 1
Horse
allograft inflammatory factor 1
Cow
allograft inflammatory factor 1
Publication Statistics
PubMed Score 2906.16
PubMed score by year
PubTator Score 333.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title