You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AIF1
Allograft inflammatory factor 1

Protein Summary
Description
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376049
  • ENSP00000365217
  • ENSG00000204472
  • ENST00000376059
  • ENSP00000365227
  • ENST00000383473
  • ENSP00000372965
  • ENSG00000206428
  • ENST00000383474
  • ENSP00000372966
  • ENST00000413349
  • ENSP00000416061
  • ENSG00000235985
  • ENST00000414149
  • ENSP00000391720
  • ENSG00000237727
  • ENST00000415830
  • ENSP00000413709
  • ENST00000416422
  • ENSP00000399901
  • ENSG00000234836
  • ENST00000419376
  • ENSP00000401433
  • ENST00000424944
  • ENSP00000399621
  • ENSG00000235588
  • ENST00000425748
  • ENSP00000398013
  • ENST00000440907
  • ENSP00000397842

Symbol
  • G1
  • IBA1
  • IBA1
  • IRT1
  • AIF-1
  • IRT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.91
gene perturbation
0.85
disease
0.79
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2906.16   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 765   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2906.16   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 765   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0