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Tbio
AICDA
Single-stranded DNA cytosine deaminase

Protein Summary
Description
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229335
  • ENSP00000229335
  • ENSG00000111732
  • ENST00000537228
  • ENSP00000445691

Symbol
  • AID
  • AID
  • ARP2
  • CDA2
  • HIGM2
  • HEL-S-284
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.97
biological process
0.93
biological term
0.76
kinase perturbation
0.66
hub protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 680.81   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 680.81   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
EXOSC3
Tbio
Novelty:  0.03072164
Score:  0.925
Data Source:  STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
Score:  0.912
Data Source:  STRINGDB
EXOSC5
Tbio
Family:  Enzyme
Novelty:  0.03352493
Score:  0.905
Data Source:  STRINGDB
EXOSC10
Tbio
Novelty:  0.00335571
Score:  0.903
Data Source:  STRINGDB
EXOSC4
Tbio
Family:  Enzyme
Novelty:  0.00798796
Score:  0.902
Data Source:  STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
Score:  0.901
Data Source:  STRINGDB
EXOSC6
Tbio
Family:  Enzyme
Novelty:  0.06031176
Score:  0.9
Data Source:  STRINGDB
EXOSC2
Tbio
Novelty:  0.08163283
Score:  0.9
Data Source:  STRINGDB
EXOSC8
Tbio
Family:  Enzyme
Novelty:  0.02013403
Score:  0.899
Data Source:  STRINGDB
EXOSC1
Tbio
Novelty:  0.01386842
Score:  0.898
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
75.4
reticulocyte measurement
1
1
1
55.2
mean platelet volume
1
1
1
55.2
diastolic blood pressure
1
1
1
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
75.4
reticulocyte measurement
1
55.2
mean platelet volume
1
55.2
diastolic blood pressure
1
32.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activation induced cytidine deaminase
VGNC:12758
473404
Macaque
activation induced cytidine deaminase
716378
Mouse
MGI:1342279
11628
Rat
RGD:1303222
399679
Dog
activation induced cytidine deaminase
VGNC:37733
442983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activation induced cytidine deaminase
Macaque
activation induced cytidine deaminase
Mouse
Rat
Dog
activation induced cytidine deaminase
Publication Statistics
PubMed Score 680.81
PubMed score by year
PubTator Score 8403.73
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title