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Tbio
AHSG
Alpha-2-HS-glycoprotein

Protein Summary
Description
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000411641
  • ENSP00000393887
  • ENSG00000145192

Symbol
  • FETUA
  • AHS
  • A2HS
  • HSGA
  • APMR1
  • FETUA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.81
biological process
0.71
gene perturbation
0.65
biological term
0.63
interacting protein
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1048.66   (req: < 5)
Gene RIFs: 223   (req: <= 3)
Antibodies: 589   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1048.66   (req: >= 5)
Gene RIFs: 223   (req: > 3)
Antibodies: 589   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (321)
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999702639
p_ni:  0.000229208
p_wrong:  0.000068153
Score:  0.229
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999051567
p_ni:  0.000925387
p_wrong:  0.000023046
Data Source:  BioPlex
USP38
Tbio
Family:  Enzyme
Novelty:  0.10350208
p_int:  0.997691439
p_ni:  0.002308561
Score:  0.534
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.989361327
p_ni:  0.010638341
p_wrong:  3.32e-7
Score:  0.25
Data Source:  BioPlex,STRINGDB
MAPK6
Tbio
Family:  Kinase
Novelty:  0.01012514
p_int:  0.969319274
p_ni:  0.000568455
p_wrong:  0.030112272
Score:  0.173
Data Source:  BioPlex,STRINGDB
CA8
Tbio
Family:  Enzyme
Novelty:  0.0041859
p_int:  0.924292121
p_ni:  0.000840347
p_wrong:  0.074867533
Score:  0.192
Data Source:  BioPlex,STRINGDB
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.922439115
p_ni:  0.000657081
p_wrong:  0.076903804
Data Source:  BioPlex
ALB
Tchem
Novelty:  0.00000616
Score:  0.998
Data Source:  STRINGDB
AFP
Tbio
Novelty:  0.00004755
Score:  0.997
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
5
6
8.1
92
calcium measurement
1
3
3
77.2
creatinine measurement
1
1
1
72.9
partial thromboplastin time
1
1
1
50.6
electrocardiography
1
1
5
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
8.1
92
calcium measurement
3
77.2
creatinine measurement
1
72.9
partial thromboplastin time
1
50.6
electrocardiography
5
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha 2-HS glycoprotein
VGNC:10476
460912
Macaque
alpha 2-HS glycoprotein
699348
Mouse
MGI:107189
11625
Rat
Dog
alpha 2-HS glycoprotein
VGNC:37731
607538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha 2-HS glycoprotein
Macaque
alpha 2-HS glycoprotein
Mouse
Rat
Dog
alpha 2-HS glycoprotein
Publication Statistics
PubMed Score 1048.66
PubMed score by year
PubTator Score 791.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title