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Tbio
AHNAK
Neuroblast differentiation-associated protein AHNAK

Protein Summary
Description
May be required for neuronal cell differentiation. The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257247
  • ENSP00000257247
  • ENSG00000124942
  • ENST00000378024
  • ENSP00000367263

Symbol
  • PM227
  • PM227
  • AHNAKRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
PubMedID
1
transcription factor perturbation
1
drug perturbation
0.96
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.61   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.61   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
JSRP1
Tdark
Novelty:  0.08386808
p_int:  0.967347924
p_ni:  0.032652076
Score:  0.507
Data Source:  BioPlex,STRINGDB
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
p_int:  0.956726824
p_ni:  0.043273176
Data Source:  BioPlex
PPL
Tbio
Novelty:  0.00684645
p_int:  0.953762294
p_ni:  0.046237706
Score:  0.878
Data Source:  BioPlex,STRINGDB
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
p_int:  0.928156287
p_ni:  0.071843713
Score:  0.167
Data Source:  BioPlex,STRINGDB
PMS1
Tbio
Family:  TF
Novelty:  0.00444827
p_int:  0.917121143
p_ni:  0.082878857
Score:  0.177
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.898242032
p_ni:  0.101757968
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.895362732
p_ni:  0.104637268
Data Source:  BioPlex
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
p_int:  0.849279055
p_ni:  0.15072094
p_wrong:  5e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.845917408
p_ni:  0.154082592
Data Source:  BioPlex
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
p_int:  0.841881851
p_ni:  0.158118149
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
4
5
97.5
waist-hip ratio
2
13
14
96.3
BMI-adjusted waist-hip ratio
5
16
17
96.2
heel bone mineral density
3
3
7
95.8
waist circumference
1
4
4
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
97.5
waist-hip ratio
14
96.3
BMI-adjusted waist-hip ratio
17
96.2
heel bone mineral density
7
95.8
waist circumference
4
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1316648
66395
Rat
RGD:619779
191572
Dog
AHNAK nucleoprotein
VGNC:37728
476059
Opossum
AHNAK nucleoprotein [Source:HGNC Symbol;Acc:HGNC:347]
Anole lizard
neuroblast differentiation-associated protein AHNAK
100556673
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
AHNAK nucleoprotein
Opossum
AHNAK nucleoprotein [Source:HGNC Symbol;Acc:HGNC:347]
Anole lizard
neuroblast differentiation-associated protein AHNAK
Publication Statistics
PubMed Score 98.61
PubMed score by year
PubTator Score 46.45
PubTator score by year
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Related Publications
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PMID
Year
Title