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Tbio
AHCYL2
Adenosylhomocysteinase 3

Protein Summary
Description
May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325006
  • ENSP00000315931
  • ENSG00000158467
  • ENST00000446544
  • ENSP00000413639
  • ENST00000474594
  • ENSP00000420459
  • ENST00000490911
  • ENSP00000420801

Symbol
  • KIAA0828
  • IRBIT2
  • ADOHCYASE3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.97
transcription factor binding site profile
0.84
transcription factor
0.8
histone modification site profile
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
HOXC9
Tbio
Family:  TF
Novelty:  0.02524418
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.999999482
p_ni:  5.18e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999996099
p_ni:  0.000003901
Score:  0.156
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999994925
p_ni:  0.000005075
Data Source:  BioPlex
ZIC2
Tbio
Family:  TF
Novelty:  0.00900257
p_int:  0.999993179
p_ni:  0.00000109
p_wrong:  0.000005731
Score:  0.15
Data Source:  BioPlex,STRINGDB
JOSD2
Tbio
Novelty:  0.27109362
p_int:  0.999992459
p_ni:  0.000007541
Data Source:  BioPlex
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
p_int:  0.999990216
p_ni:  0.000009784
Data Source:  BioPlex
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.999978765
p_ni:  0.000021235
Data Source:  BioPlex
ABCF2
Tbio
Family:  Transporter
Novelty:  0.06782708
p_int:  0.999969714
p_ni:  0.000030286
Score:  0.276
Data Source:  BioPlex,STRINGDB
FAM13C
Tdark
Novelty:  0.63294359
p_int:  0.99996191
p_ni:  0.00003809
Score:  0.303
Data Source:  BioPlex,STRINGDB
Pathways (17)
Bicarbonate transporters (R-HSA-425381)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.8
67.5
hemoglobin measurement
2
1
2
57.5
hematocrit
2
1
2
55
Drugs used in diabetes use measurement
2
1
2
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.8
67.5
hemoglobin measurement
2
57.5
hematocrit
2
55
Drugs used in diabetes use measurement
2
0.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosylhomocysteinase like 2
VGNC:7210
463719
Macaque
adenosylhomocysteinase like 2
703491
Mouse
MGI:1921590
74340
Rat
RGD:1564895
312192
Dog
adenosylhomocysteinase like 2
VGNC:37726
475197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosylhomocysteinase like 2
Macaque
adenosylhomocysteinase like 2
Mouse
Rat
Dog
adenosylhomocysteinase like 2
Publication Statistics
PubMed Score 11.97
PubMed score by year
PubTator Score 2.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title