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Tbio
AGTRAP
Type-1 angiotensin II receptor-associated protein

Protein Summary
Description
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314340
  • ENSP00000319713
  • ENSG00000177674
  • ENST00000376629
  • ENSP00000365816
  • ENST00000376637
  • ENSP00000365824
  • ENST00000400895
  • ENSP00000383688
  • ENST00000452018
  • ENSP00000408505

Symbol
  • ATRAP
  • ATRAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
cellular component
0.69
PubMedID
0.69
transcription factor
0.68
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.98   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.98   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.999999841
p_ni:  6.5e-8
p_wrong:  9.4e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.999999465
p_ni:  5.03e-7
p_wrong:  3.3e-8
Data Source:  BioPlex
PAFAH2
Tbio
Family:  Enzyme
Novelty:  0.19881779
p_int:  0.999998791
p_ni:  0.000001194
p_wrong:  1.5e-8
Data Source:  BioPlex
TMEM47
Tdark
Novelty:  0.1571161
p_int:  0.999795224
p_ni:  0.000127028
p_wrong:  0.000077747
Data Source:  BioPlex
ENPP6
Tbio
Family:  Enzyme
Novelty:  0.06933544
p_int:  0.907187282
p_ni:  0.000001939
p_wrong:  0.092810779
Score:  0.204
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.902438725
p_ni:  0.000677773
p_wrong:  0.096883502
Data Source:  BioPlex
G0S2
Tbio
Novelty:  0.02273959
p_int:  0.770925357
p_ni:  0.000149825
p_wrong:  0.228924817
Data Source:  BioPlex
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.766751451
p_ni:  0.000003168
p_wrong:  0.233245381
Score:  0.189
Data Source:  BioPlex,STRINGDB
CLCN6
Tchem
Family:  IC
Novelty:  0.02775193
Score:  0.955
Data Source:  STRINGDB
CAMLG
Tbio
Novelty:  0.0088918
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
3
2
4
95.1
diastolic blood pressure
3
2
3
87.5
1
1
1
81.1
mean corpuscular hemoglobin concentration
1
1
1
79
hip circumference
1
6
6
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
4
95.1
diastolic blood pressure
3
87.5
1
81.1
mean corpuscular hemoglobin concentration
1
79
hip circumference
6
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
angiotensin II receptor associated protein
722746
Mouse
MGI:1339977
11610
Rat
RGD:1359346
298646
Dog
angiotensin II receptor associated protein
VGNC:37722
608333
Horse
angiotensin II receptor associated protein
VGNC:15175
100051052
Species
Name
OMA
EggNOG
Inparanoid
Macaque
angiotensin II receptor associated protein
Mouse
Rat
Dog
angiotensin II receptor associated protein
Horse
angiotensin II receptor associated protein
Publication Statistics
PubMed Score 56.98
PubMed score by year
PubTator Score 16.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title