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Tchem
AGTR2
Type-2 angiotensin II receptor

Protein Summary
Description
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371906
  • ENSP00000360973
  • ENSG00000180772

Symbol
  • AT2
  • ATGR2
  • MRX88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.79
gene perturbation
0.76
chemical
0.68
disease
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1503.32   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1503.32   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 251
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (251)
Protein-Protein Interactions (329)
AGT
Tbio
Novelty:  0.00049613
Score:  0.993
Data Source:  Reactome,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.966
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.956
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.947
Data Source:  STRINGDB
EDN2
Tbio
Novelty:  0.00203492
Score:  0.945
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.944
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.944
Data Source:  STRINGDB
ADRA2C
Tclin
Family:  GPCR
Novelty:  0.00661399
Score:  0.942
Data Source:  STRINGDB
ADRA2A
Tclin
Family:  GPCR
Novelty:  0.00273659
Score:  0.941
Data Source:  STRINGDB
ADRA2B
Tclin
Family:  GPCR
Novelty:  0.00633206
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
2
2
6
1
1
0
6.8
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
2
6
0
6.8
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
angiotensin II receptor type 2
709513
Mouse
MGI:87966
11609
Rat
RGD:2072
24182
Dog
angiotensin II receptor type 2
VGNC:37721
403835
Horse
angiotensin II receptor type 2
VGNC:15174
100053878
Species
Name
OMA
EggNOG
Inparanoid
Macaque
angiotensin II receptor type 2
Mouse
Rat
Dog
angiotensin II receptor type 2
Horse
angiotensin II receptor type 2
Publication Statistics
PubMed Score 1503.32
PubMed score by year
PubTator Score 667.93
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title