AGTR2
Type-2 angiotensin II receptor
Protein Summary
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. [provided by RefSeq, Jan 2010]
- ENST00000371906
- ENSP00000360973
- ENSG00000180772
- AT2
- ATGR2
- MRX88
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.79 | ||
gene perturbation | 0.76 | ||
chemical | 0.68 | ||
disease | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1791.41 (req: < 5)
Gene RIFs: 168 (req: <= 3)
Antibodies: 239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1791.41 (req: >= 5)
Gene RIFs: 168 (req: > 3)
Antibodies: 239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 265
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4