Protein Summary
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin conve ...more
- ENST00000366667
- ENSP00000355627
- ENSG00000135744
- SERPINA8
- ANHU
- hFLT1
- SERPINA8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
disease perturbation | 0.87 | ||
disease | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1875.86 (req: < 5)
Gene RIFs: 591 (req: <= 3)
Antibodies: 928 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1875.86 (req: >= 5)
Gene RIFs: 591 (req: > 3)
Antibodies: 928 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 98
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (585)
RIPK4
Family: Kinase
Novelty: 0.00818379
p_int: 0.968270485
p_ni: 0.029067675
p_wrong: 0.002661841
Score: 0.209
Data Source: BioPlex,STRINGDB
NDUFA3
Family: Enzyme
Novelty: 0.21111937
p_int: 0.847857514
p_ni: 0.141990399
p_wrong: 0.010152087
Score: 0.219
Data Source: BioPlex,STRINGDB
CANX
Novelty: 0.00087002
p_int: 0.84649898
p_ni: 0.15350102
Score: 0.17
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00043424
p_int: 0.845725347
p_ni: 0.154274653
Score: 0.199
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (51)
Reactome (15)
KEGG (14)
PathwayCommons (9)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (103)
Functions (8)
Components (5)
Processes (90)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 1 | 1 | 62.1 | |||||
2 | 2 | 2 | 37.3 | ||||||
Beta blocking agent use measurement | 1 | 1 | 1 | 36.9 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 36.5 | |||||
response to radiation | 1 | 1 | 0 | 1.9 | 21.5 | ||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 62.1 | |||||
2 | 37.3 | ||||||
Beta blocking agent use measurement | 1 | 36.9 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 36.5 | |||||
response to radiation | 0 | 1.9 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | angiotensinogen | VGNC:40 | 450104 | |||||
Macaque | angiotensinogen | 714203 | ||||||
Mouse | MGI:87963 | 11606 | ||||||
Rat | RGD:2069 | 24179 | ||||||
Dog | angiotensinogen | VGNC:37718 | 403783 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | angiotensinogen | |||||
Macaque | angiotensinogen | |||||
Mouse | ||||||
Rat | ||||||
Dog | angiotensinogen | |||||
Publication Statistics
PubMed Score 1875.86
PubMed score by year
PubTator Score 12223.94
PubTator score by year
Related Publications
Text Mined References (1022)
GeneRif Annotations (591)
Items per page:
0 of 0
PMID | Year | Title |
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