Pharos : Target Details

Tbio

Protein Summary

Description

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3: stimulates aldosterone release. Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin conve ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000366667
ENSP00000355627
ENSG00000135744

Symbol

SERPINA8
ANHU
hFLT1
SERPINA8

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1

biological term	1

chemical	1

disease perturbation	0.87

disease	0.84

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1977.93 (req: < 5)

View Publications

Gene RIFs: 591 (req: <= 3)

View Gene RIFs

Antibodies: 928 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1977.93 (req: >= 5)

Gene RIFs: 591 (req: > 3)

Antibodies: 928 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 98

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (585)

Explore Interacting Targets

1 – 10 of 585

See Interactions on String-DB

RIPK4

Tchem

Family: Kinase

Novelty: 0.00818379

p_int: 0.968270485

p_ni: 0.029067675

p_wrong: 0.002661841

Score: 0.209

Data Source: BioPlex,STRINGDB

NDUFA3

Tclin

Family: Enzyme

Novelty: 0.21111937

p_int: 0.847857514

p_ni: 0.141990399

p_wrong: 0.010152087

Score: 0.219

Data Source: BioPlex,STRINGDB

CANX

Tbio

Novelty: 0.00087002

p_int: 0.84649898

p_ni: 0.15350102

Score: 0.17

Data Source: BioPlex,STRINGDB

HSPA5

Tchem

Novelty: 0.00043424

p_int: 0.845725347

p_ni: 0.154274653

Score: 0.199

Data Source: BioPlex,STRINGDB

REN

Tclin

Family: Enzyme

Novelty: 0.00002435

Score: 0.999