Protein Summary
Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release f ...more
- ENST00000379370
- ENSP00000368678
- ENSG00000188157
- AGRIN
- CMS8
- AGRIN
- CMSPPD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
biological process | 0.95 | ||
molecular function | 0.88 | ||
virus perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 686.57 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 199 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 686.57 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 199 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (199)
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999985397
p_ni: 0.000014596
p_wrong: 8e-9
Score: 0.202
Data Source: BioPlex,STRINGDB
HADHA
Novelty: 0.00385746
p_int: 0.999979003
p_ni: 0.000020985
p_wrong: 1.2e-8
Data Source: BioPlex
CRP
Novelty: 0.00001517
p_int: 0.999966555
p_ni: 0.000033443
p_wrong: 2e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
OS9
Novelty: 0.01490339
p_int: 0.999626037
p_ni: 0.00035002
p_wrong: 0.000023943
Data Source: BioPlex
MAX
Family: TF
Novelty: 0.00799068
p_int: 0.996951098
p_ni: 0.002882733
p_wrong: 0.000166168
Data Source: BioPlex
CCL3L1
Novelty: 0.01124082
p_int: 0.991257591
p_ni: 0.008725881
p_wrong: 0.000016528
Data Source: BioPlex
ZFP41
Family: TF
Novelty: 3.33093006
p_int: 0.852737425
p_ni: 0.000225314
p_wrong: 0.147037261
Data Source: BioPlex
OLFM3
Novelty: 0.10234408
p_int: 0.847916659
p_ni: 0.000771509
p_wrong: 0.151311832
Score: 0.282
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (88)
Reactome (32)
KEGG (1)
PathwayCommons (8)
WikiPathways (47)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Axon guidance | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Reactome | Defective B3GAT3 causes JDSSDHD | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Axon guidance | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Defective B3GAT3 causes JDSSDHD | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (8)
Components (11)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.3 | 59.6 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 52 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 47.4 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 46.9 | |||||
hip bone size | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.3 | 59.6 | |||||
apolipoprotein A 1 measurement | 2 | 52 | |||||
high density lipoprotein cholesterol measurement | 2 | 47.4 | |||||
alkaline phosphatase measurement | 1 | 46.9 | |||||
hip bone size | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
Publication Statistics
PubMed Score 686.57
PubMed score by year
PubTator Score 375.31
PubTator score by year
Related Publications
Text Mined References (55)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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