You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
AGPAT2
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

Protein Summary
Description
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371694
  • ENSP00000360759
  • ENSG00000169692
  • ENST00000371696
  • ENSP00000360761
  • ENST00000538402
  • ENSP00000438919

Symbol
  • BSCL
  • BSCL1
  • LPAAB
  • 1-AGPAT2
  • LPAAT-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
kinase perturbation
0.71
disease perturbation
0.68
cellular component
0.67
PubMedID
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.36   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.36   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (208)
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.994873514
p_ni:  0.005126379
p_wrong:  1.07e-7
Score:  0.507
Data Source:  BioPlex,STRINGDB
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.960114264
p_ni:  0.039885736
Score:  0.181
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.885300323
p_ni:  0.114699676
Score:  0.163
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.772408949
p_ni:  0.227591051
Data Source:  BioPlex
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.7691417
p_ni:  0.230858291
p_wrong:  9e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.979
Data Source:  STRINGDB
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.972
Data Source:  STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
Score:  0.972
Data Source:  STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.972
Data Source:  STRINGDB
GPAT2
Tbio
Family:  Enzyme
Novelty:  0.03807198
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (21)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
38.8
diastolic blood pressure
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
38.8
diastolic blood pressure
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 2
VGNC:4603
748669
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 2
709753
Mouse
MGI:1914762
67512
Rat
RGD:1309229
311821
Dog
1-acylglycerol-3-phosphate O-acyltransferase 2
VGNC:37711
491249
Species
Name
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 2
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 2
Mouse
Rat
Dog
1-acylglycerol-3-phosphate O-acyltransferase 2
Publication Statistics
PubMed Score 88.36
PubMed score by year
PubTator Score 71.86
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title