AGPAT1
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Protein Summary
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000336984
- ENSP00000337463
- ENSG00000204310
- ENST00000375104
- ENSP00000364245
- ENST00000375107
- ENSP00000364248
- ENST00000383294
- ENSP00000372782
- ENSG00000206324
- ENST00000395496
- ENSP00000378874
- ENST00000395497
- ENSP00000378875
- ENST00000395499
- ENSP00000378877
- ENST00000399825
- ENSP00000382721
- ENST00000399827
- ENSP00000382723
- ENST00000399829
- ENSP00000382725
- ENST00000399830
- ENSP00000382726
- ENST00000399833
- ENSP00000382728
- ENST00000414520
- ENSP00000406615
- ENSG00000227642
- ENST00000414933
- ENSP00000388870
- ENST00000415173
- ENSP00000412805
- ENSG00000228892
- ENST00000416363
- ENSP00000407189
- ENSG00000236873
- ENST00000417388
- ENSP00000415015
- ENST00000424030
- ENSP00000397765
- ENST00000425204
- ENSP00000388253
- ENSG00000226467
- ENST00000425572
- ENSP00000394919
- ENSG00000235758
- ENST00000427763
- ENSP00000401410
- ENST00000430226
- ENSP00000412304
- ENST00000430777
- ENSP00000392820
- ENST00000433376
- ENSP00000387810
- ENST00000433896
- ENSP00000408842
- ENST00000434614
- ENSP00000401287
- ENST00000436149
- ENSP00000388090
- ENST00000439774
- ENSP00000398016
- ENST00000440840
- ENSP00000395863
- ENST00000444369
- ENSP00000408032
- ENST00000446323
- ENSP00000392083
- ENST00000446463
- ENSP00000405864
- ENST00000448196
- ENSP00000404106
- ENST00000449776
- ENSP00000410831
- ENST00000451833
- ENSP00000406582
- ENST00000452393
- ENSP00000406614
- ENST00000452427
- ENSP00000387738
- ENST00000454929
- ENSP00000390988
- ENST00000455898
- ENSP00000395613
- ENST00000456421
- ENSP00000389516
- ENST00000456679
- ENSP00000388815
- ENST00000457923
- ENSP00000405565
- G15
- G15
- LPAATA
- 1-AGPAT1
- LPAAT-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.9 | ||
transcription factor binding site profile | 0.83 | ||
transcription factor | 0.82 | ||
gene perturbation | 0.81 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.51 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.51 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0