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Tbio
AGPAT1
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Protein Summary
Description
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336984
  • ENSP00000337463
  • ENSG00000204310
  • ENST00000375104
  • ENSP00000364245
  • ENST00000375107
  • ENSP00000364248
  • ENST00000383294
  • ENSP00000372782
  • ENSG00000206324
  • ENST00000395496
  • ENSP00000378874
  • ENST00000395497
  • ENSP00000378875
  • ENST00000395499
  • ENSP00000378877
  • ENST00000399825
  • ENSP00000382721
  • ENST00000399827
  • ENSP00000382723
  • ENST00000399829
  • ENSP00000382725
  • ENST00000399830
  • ENSP00000382726
  • ENST00000399833
  • ENSP00000382728
  • ENST00000414520
  • ENSP00000406615
  • ENSG00000227642
  • ENST00000414933
  • ENSP00000388870
  • ENST00000415173
  • ENSP00000412805
  • ENSG00000228892
  • ENST00000416363
  • ENSP00000407189
  • ENSG00000236873
  • ENST00000417388
  • ENSP00000415015
  • ENST00000424030
  • ENSP00000397765
  • ENST00000425204
  • ENSP00000388253
  • ENSG00000226467
  • ENST00000425572
  • ENSP00000394919
  • ENSG00000235758
  • ENST00000427763
  • ENSP00000401410
  • ENST00000430226
  • ENSP00000412304
  • ENST00000430777
  • ENSP00000392820
  • ENST00000433376
  • ENSP00000387810
  • ENST00000433896
  • ENSP00000408842
  • ENST00000434614
  • ENSP00000401287
  • ENST00000436149
  • ENSP00000388090
  • ENST00000439774
  • ENSP00000398016
  • ENST00000440840
  • ENSP00000395863
  • ENST00000444369
  • ENSP00000408032
  • ENST00000446323
  • ENSP00000392083
  • ENST00000446463
  • ENSP00000405864
  • ENST00000448196
  • ENSP00000404106
  • ENST00000449776
  • ENSP00000410831
  • ENST00000451833
  • ENSP00000406582
  • ENST00000452393
  • ENSP00000406614
  • ENST00000452427
  • ENSP00000387738
  • ENST00000454929
  • ENSP00000390988
  • ENST00000455898
  • ENSP00000395613
  • ENST00000456421
  • ENSP00000389516
  • ENST00000456679
  • ENSP00000388815
  • ENST00000457923
  • ENSP00000405565

Symbol
  • G15
  • G15
  • LPAATA
  • 1-AGPAT1
  • LPAAT-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.83
transcription factor
0.82
gene perturbation
0.81
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.99   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.99   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
RNASEH2A
Tbio
Family:  Enzyme
Novelty:  0.00478657
p_int:  0.980864772
p_ni:  0.019135227
Score:  0.383
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.919378442
p_ni:  0.080621558
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.803045016
p_ni:  0.196954983
p_wrong:  1e-9
Data Source:  BioPlex
TNFRSF17
Tclin
Novelty:  0.00222663
p_int:  0.761330869
p_ni:  0.238669122
p_wrong:  9e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.978
Data Source:  STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.978
Data Source:  STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
Score:  0.973
Data Source:  STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.972
Data Source:  STRINGDB
GPAT2
Tbio
Family:  Enzyme
Novelty:  0.03807198
Score:  0.961
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (34)
ChREBP activates metabolic gene expression (R-HSA-163765)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ChREBP activates metabolic gene expression
Reactome
Glycerophospholipid biosynthesis
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
ChREBP activates metabolic gene expression
Glycerophospholipid biosynthesis
Integration of energy metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (546)
Items per page:
1 – 5 of 546
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
Items per page:
1 – 5 of 546
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 1
VGNC:12570
462582
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 1
717174
Mouse
MGI:1932075
55979
Rat
RGD:1303287
406165
Dog
1-acylglycerol-3-phosphate O-acyltransferase 1
VGNC:37710
474857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 1
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 1
Mouse
Rat
Dog
1-acylglycerol-3-phosphate O-acyltransferase 1
Publication Statistics
PubMed Score 17.99
PubMed score by year
PubTator Score 17.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title