Tbio AGO4 Protein argonaute-4

Protein Summary

Description

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9HCK5
• A7MD27
• Argonaute4

Gene Name

• AGO4

Ensembl ID

• ENST00000373210
• ENSP00000362306
• ENSG00000134698

Symbol

• EIF2C4
• KIAA1567
• EIF2C4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
microRNA	0.86
biological process	0.8
histone modification site profile	0.74
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.7   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.7   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (215)

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1 – 10 of 215

• See Interactions on String-DB

ANKMY2

Tdark

Novelty:  0.50777631

p_int:  0.998539718

p_ni:  1.1e-8

p_wrong:  0.001460272

Score:  0.484

Data Source:  BioPlex,STRINGDB

PITRM1

Tchem

Family:  Enzyme

Novelty:  0.08067518

p_int:  0.992539276

p_ni:  0.000001017

p_wrong:  0.007459708

Data Source:  BioPlex

DICER1

Tbio

Family:  Enzyme

Novelty:  0.000306

Score:  0.996

Data Source:  STRINGDB

TNRC6C

Tbio

Novelty:  0.09764186

Score:  0.983

Data Source:  Reactome,STRINGDB

TNRC6A

Tbio

Novelty:  0.00505282

Score:  0.981

Data Source:  Reactome,STRINGDB

XPO5

Tbio

Novelty:  0.0040002

Score:  0.971

Data Source:  STRINGDB

TARBP2

Tbio

Novelty:  0.01485994

Score:  0.968

Data Source:  STRINGDB

TNRC6B

Tbio

Novelty:  0.04520863

Score:  0.967

Data Source:  Reactome,STRINGDB

DROSHA

Tbio

Family:  Enzyme

Novelty:  0.00107123

Score:  0.954

Data Source:  STRINGDB

MOV10

Tbio

Family:  Enzyme

Novelty:  0.01963275

Score:  0.948

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (36)

Reactome (36)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (3)

Components (9)

Processes (17)

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1 – 3 of 3

GO Term	Evidence	Assigned by
double-stranded RNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
miRNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
single-stranded RNA binding	Inferred from Direct Assay (IDA)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		59
schizophrenia	EFO_0000692	1	1	0	1.1	15.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1		59
schizophrenia	EFO_0000692	0	1.1	15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Reference proteome
Ribonucleoprotein
RNA-binding
RNA-mediated gene silencing
Translation regulation

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration
schizophrenia

MGI Phenotype Find Similar Targets

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cellular phenotype
endocrine/exocrine gland phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	argonaute 4, RISC catalytic component	VGNC:38	469278
Macaque	argonaute 4, RISC catalytic component		713134
Mouse	argonaute RISC catalytic subunit 4	MGI:1924100	76850
Zebrafish	argonaute RISC catalytic component 4	ZDB-GENE-030131-5357	100535764
C. elegans	Protein argonaute		173468

Species	Name	OMA	EggNOG	Inparanoid
Chimp	argonaute 4, RISC catalytic component
Macaque	argonaute 4, RISC catalytic component
Mouse	argonaute RISC catalytic subunit 4
Zebrafish	argonaute RISC catalytic component 4
C. elegans	Protein argonaute

Publication Statistics

PubMed Score 235.70

PubMed score by year

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PubTator Score 38.64

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (4)

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PMID	Year	Title