Tbio AGO4 Protein argonaute-4

Protein Summary

Description

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9HCK5
• A7MD27
• Argonaute4

Gene Name

• AGO4

Ensembl ID

• ENST00000373210
• ENSP00000362306
• ENSG00000134698

Symbol

• EIF2C4
• KIAA1567
• EIF2C4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
microRNA	0.86
biological process	0.8
histone modification site profile	0.74
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.1   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.1   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0