Protein Summary
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t ...more
- ENST00000220592
- ENSP00000220592
- ENSG00000123908
- ENST00000519980
- ENSP00000430176
- EIF2C2
- PPD
- Q10
- CASC7
- EIF2C2
- LINC00980
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
biological process | 0.96 | ||
hub protein | 0.95 | ||
interacting protein | 0.95 | ||
transcription factor binding site profile | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1792.76 (req: < 5)
Gene RIFs: 182 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1792.76 (req: >= 5)
Gene RIFs: 182 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (322)
ANKRD40
Novelty: 1.06633958
p_int: 0.963604529
p_ni: 0.036395466
p_wrong: 5e-9
Data Source: BioPlex
POTEF
Novelty: 0.00191599
p_int: 0.944171738
p_ni: 0.055703256
p_wrong: 0.000125006
Score: 0.247
Data Source: BioPlex,STRINGDB
AGO1
Novelty: 0.00157424
p_int: 0.771446031
p_ni: 0.228553969
Score: 0.974
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (47)
Reactome (31)
WikiPathways (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | ||||
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Competing endogenous RNAs (ceRNAs) regulate PTEN translation | ||||
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Viral Interactions (0)
Gene Ontology Terms (55)
Functions (15)
Components (15)
Processes (25)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 78 | |||||
mathematical ability | 2 | 2 | 2 | 58.9 | |||||
mean corpuscular volume | 1 | 1 | 1 | 56.8 | |||||
2 | 2 | 0 | 1 | 55.8 | |||||
cognitive function measurement | 3 | 1 | 3 | 55.2 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 78 | |||||
mathematical ability | 2 | 58.9 | |||||
mean corpuscular volume | 1 | 56.8 | |||||
0 | 1 | 55.8 | |||||
cognitive function measurement | 3 | 55.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | argonaute 2, RISC catalytic component | VGNC:11954 | 737376 | |||||
Macaque | argonaute 2, RISC catalytic component | 711873 | ||||||
Mouse | MGI:2446632 | 239528 | ||||||
Rat | RGD:621255 | 59117 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | argonaute 2, RISC catalytic component | |||||
Macaque | argonaute 2, RISC catalytic component | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 1792.76
PubMed score by year
PubTator Score 558.73
PubTator score by year
Related Publications
Text Mined References (247)
GeneRif Annotations (182)
Items per page:
0 of 0
PMID | Year | Title |
---|