Pharos : Target Details

Tbio

Protein Summary

Description

Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t ...more

Uniprot Accession IDs

Gene Name

AGO2

Ensembl ID

ENST00000220592
ENSP00000220592
ENSG00000123908
ENST00000519980
ENSP00000430176

Symbol

EIF2C2
PPD
Q10
CASC7
EIF2C2
LINC00980

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1

biological process	0.96

hub protein	0.95

interacting protein	0.95

transcription factor binding site profile	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1792.76 (req: < 5)

View Publications

Gene RIFs: 182 (req: <= 3)

View Gene RIFs

Antibodies: 285 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1792.76 (req: >= 5)

Gene RIFs: 182 (req: > 3)

Antibodies: 285 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (322)

Explore Interacting Targets

1 – 10 of 322

See Interactions on String-DB

MTIF2

Tbio

Novelty: 0.06681774

p_int: 0.999680754

p_ni: 0.000319246

Data Source: BioPlex

ANKRD40

Tdark

Novelty: 1.06633958

p_int: 0.963604529

p_ni: 0.036395466

p_wrong: 5e-9

Data Source: BioPlex

POTEF

Tbio

Novelty: 0.00191599

p_int: 0.944171738

p_ni: 0.055703256

p_wrong: 0.000125006

Score: 0.247

Data Source: BioPlex,STRINGDB

AGO1

Tbio

Novelty: 0.00157424

p_int: 0.771446031

p_ni: 0.228553969

Score: 0.974

Data Source: BioPlex,STRINGDB

TNRC6A

Tbio

Novelty: 0.00505282

Score: 0.999