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Tbio
AGO2
Protein argonaute-2

Protein Summary
Description
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220592
  • ENSP00000220592
  • ENSG00000123908
  • ENST00000519980
  • ENSP00000430176

Symbol
  • EIF2C2
  • PPD
  • Q10
  • CASC7
  • EIF2C2
  • LINC00980
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.96
hub protein
0.95
interacting protein
0.95
transcription factor binding site profile
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1792.76   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1792.76   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (322)
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.999680754
p_ni:  0.000319246
Data Source:  BioPlex
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.963604529
p_ni:  0.036395466
p_wrong:  5e-9
Data Source:  BioPlex
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.944171738
p_ni:  0.055703256
p_wrong:  0.000125006
Score:  0.247
Data Source:  BioPlex,STRINGDB
AGO1
Tbio
Novelty:  0.00157424
p_int:  0.771446031
p_ni:  0.228553969
Score:  0.974
Data Source:  BioPlex,STRINGDB
TNRC6A
Tbio
Novelty:  0.00505282
Score:  0.999
Data Source:  Reactome,STRINGDB
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
Score:  0.999
Data Source:  Reactome,STRINGDB
TARBP2
Tbio
Novelty:  0.01485994
Score:  0.996
Data Source:  Reactome,STRINGDB
TNRC6C
Tbio
Novelty:  0.09764186
Score:  0.994
Data Source:  Reactome,STRINGDB
TNRC6B
Tbio
Novelty:  0.04520863
Score:  0.99
Data Source:  Reactome,STRINGDB
XPO5
Tbio
Novelty:  0.0040002
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
ESR-mediated signaling
Estrogen-dependent gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
78
mathematical ability
2
2
2
58.9
mean corpuscular volume
1
1
1
56.8
2
2
0
1
55.8
cognitive function measurement
3
1
3
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
78
mathematical ability
2
58.9
mean corpuscular volume
1
56.8
0
1
55.8
cognitive function measurement
3
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
argonaute 2, RISC catalytic component
VGNC:11954
737376
Macaque
argonaute 2, RISC catalytic component
711873
Mouse
MGI:2446632
239528
Rat
RGD:621255
59117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
argonaute 2, RISC catalytic component
Macaque
argonaute 2, RISC catalytic component
Mouse
Rat
Publication Statistics
PubMed Score 1792.76
PubMed score by year
PubTator Score 558.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title