Tbio AGO1 Protein argonaute-1

Protein Summary

Description

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q9UL18
• Q5TA57
• Q6P4S0
• Argonaute1

Gene Name

• AGO1

Ensembl ID

• ENST00000373204
• ENSP00000362300
• ENSG00000092847

Symbol

• EIF2C1
• Q99
• EIF2C
• hAgo1
• EIF2C1
• GERP95

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
pathway	0.99
hub protein	0.94
interacting protein	0.94
biological process	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 713.16   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 713.16   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (286)

Explore Interacting Targets

1 – 10 of 286

• See Interactions on String-DB

HSP90AA4P

Tdark

p_int:  0.999996792

p_ni:  0.000003203

p_wrong:  5e-9

Data Source:  BioPlex

FKBP5

Tchem

Family:  Enzyme

Novelty:  0.00214511

p_int:  0.999984227

p_ni:  0.000015773

Score:  0.383

Data Source:  BioPlex,STRINGDB

DICER1

Tbio

Family:  Enzyme

Novelty:  0.000306

p_int:  0.999931265

p_ni:  0.000068735

Score:  0.999

Data Source:  BioPlex,STRINGDB

TARBP2

Tbio

Novelty:  0.01485994

p_int:  0.999915989

p_ni:  0.000084011

Score:  0.983

Data Source:  BioPlex,STRINGDB

HSP90AA5P

Tdark

p_int:  0.999679815

p_ni:  0.000318342

p_wrong:  0.000001844

Data Source:  BioPlex

HSP90AB4P

Tdark

p_int:  0.999605546

p_ni:  0.000394274

p_wrong:  1.79e-7

Data Source:  BioPlex

AGO3

Tbio

Novelty:  0.01664154

p_int:  0.99907898

p_ni:  0.00092102

Score:  0.974

Data Source:  BioPlex,STRINGDB

TRMT13

Tdark

Novelty:  3.91234304

p_int:  0.996574534

p_ni:  0.003393883

p_wrong:  0.000031584

Data Source:  BioPlex

HSP90AB1

Tchem

Novelty:  0.00907961

p_int:  0.987080454

p_ni:  0.012919546

Score:  0.353

Data Source:  BioPlex,STRINGDB

RBMS1

Tbio

Novelty:  0.00520684

p_int:  0.983330347

p_ni:  0.013018736

p_wrong:  0.003650917

Score:  0.235

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (37)

Reactome (37)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (34)

Functions (7)

Components (10)

Processes (17)

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1 – 7 of 7

GO Term	Evidence	Assigned by
double-stranded RNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
miRNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II complex binding	Inferred from Direct Assay (IDA)	BHF-UCL
single-stranded RNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
core promoter binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
bone density	EFO_0003923	1	1	2		59.6
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		59
schizophrenia	EFO_0000692	1	1	0	1.1	15.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
bone density	EFO_0003923	2		59.6
mean corpuscular hemoglobin concentration	EFO_0004528	1		59
schizophrenia	EFO_0000692	0	1.1	15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Cytoplasm
Disease mutation
Reference proteome
Repressor
Ribonucleoprotein
RNA-binding
RNA-mediated gene silencing
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
bone density
mean corpuscular hemoglobin concentration
schizophrenia

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	argonaute 1, RISC catalytic component	VGNC:36	456747
Macaque	argonaute 1, RISC catalytic component		712398
Mouse	argonaute RISC catalytic subunit 1	MGI:2446630	236511
Rat	argonaute 1, RISC catalytic component	RGD:1304619	313594
Pig	protein argonaute-3 [Source:RefSeq peptide;Acc:NP_001181903]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	argonaute 1, RISC catalytic component
Macaque	argonaute 1, RISC catalytic component
Mouse	argonaute RISC catalytic subunit 1
Rat	argonaute 1, RISC catalytic component
Pig	protein argonaute-3 [Source:RefSeq peptide;Acc:NP_001181903]

Publication Statistics

PubMed Score 713.16

PubMed score by year

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PubTator Score 139.62

PubTator score by year

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Related Publications

Text Mined References (77)

GeneRif Annotations (41)

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PMID	Year	Title