Protein Summary
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have ...more
- ENST00000373204
- ENSP00000362300
- ENSG00000092847
- EIF2C1
- Q99
- EIF2C
- hAgo1
- EIF2C1
- GERP95
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.99 | ||
pathway | 0.99 | ||
hub protein | 0.94 | ||
interacting protein | 0.94 | ||
biological process | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 713.16 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 713.16 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (286)
FKBP5
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999984227
p_ni: 0.000015773
Score: 0.383
Data Source: BioPlex,STRINGDB
DICER1
Family: Enzyme
Novelty: 0.000306
p_int: 0.999931265
p_ni: 0.000068735
Score: 0.999
Data Source: BioPlex,STRINGDB
TARBP2
Novelty: 0.01485994
p_int: 0.999915989
p_ni: 0.000084011
Score: 0.983
Data Source: BioPlex,STRINGDB
AGO3
Novelty: 0.01664154
p_int: 0.99907898
p_ni: 0.00092102
Score: 0.974
Data Source: BioPlex,STRINGDB
TRMT13
Novelty: 3.91234304
p_int: 0.996574534
p_ni: 0.003393883
p_wrong: 0.000031584
Data Source: BioPlex
HSP90AB1
Novelty: 0.00907961
p_int: 0.987080454
p_ni: 0.012919546
Score: 0.353
Data Source: BioPlex,STRINGDB
RBMS1
Novelty: 0.00520684
p_int: 0.983330347
p_ni: 0.013018736
p_wrong: 0.003650917
Score: 0.235
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (37)
Reactome (37)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (7)
Components (10)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
bone density | 1 | 1 | 2 | 59.6 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 59 | |||||
1 | 1 | 0 | 1.1 | 15.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
bone density | 2 | 59.6 | |||||
mean corpuscular hemoglobin concentration | 1 | 59 | |||||
0 | 1.1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | argonaute 1, RISC catalytic component | VGNC:36 | 456747 | |||||
Macaque | argonaute 1, RISC catalytic component | 712398 | ||||||
Mouse | MGI:2446630 | 236511 | ||||||
Rat | RGD:1304619 | 313594 | ||||||
Pig | protein argonaute-3 [Source:RefSeq peptide;Acc:NP_001181903] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | argonaute 1, RISC catalytic component | |||||
Macaque | argonaute 1, RISC catalytic component | |||||
Mouse | ||||||
Rat | ||||||
Pig | protein argonaute-3 [Source:RefSeq peptide;Acc:NP_001181903] | |||||
Publication Statistics
PubMed Score 713.16
PubMed score by year
PubTator Score 139.62
PubTator score by year
Related Publications
Text Mined References (77)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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