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Tbio
AGK
Acylglycerol kinase, mitochondrial

Protein Summary
Description
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355413
  • ENSP00000347581
  • ENSG00000006530
  • ENST00000492693
  • ENSP00000418789
  • ENST00000575872
  • ENSP00000458417
  • ENSG00000262327
  • ENST00000648068
  • ENSP00000498112
  • ENST00000649286
  • ENSP00000497280
  • ENST00000650547
  • ENSP00000496789

Symbol
  • MULK
  • MULK
  • CATC5
  • CTRCT38
  • MTDPS10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.94
histone modification site profile
0.9
metabolite
0.84
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.95   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.95   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
p_int:  0.999999962
p_ni:  1.6e-8
p_wrong:  2.2e-8
Score:  0.927
Data Source:  BioPlex,STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.999893966
p_ni:  0.000106034
Score:  0.181
Data Source:  BioPlex,STRINGDB
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
p_int:  0.998609195
p_ni:  0.001390805
Score:  0.544
Data Source:  BioPlex,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.986386317
p_ni:  0.013613683
Score:  0.937
Data Source:  BioPlex,STRINGDB
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.969535939
p_ni:  0.030464061
Data Source:  BioPlex
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.927630362
p_ni:  0.072369556
p_wrong:  8.2e-8
Data Source:  BioPlex
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.891175838
p_ni:  0.108824162
Score:  0.158
Data Source:  BioPlex,STRINGDB
RAB18
Tbio
Family:  Enzyme
Novelty:  0.01548795
p_int:  0.778169983
p_ni:  0.221830017
Score:  0.191
Data Source:  BioPlex,STRINGDB
KIAA1549
Tbio
Novelty:  0.01224835
Score:  0.938
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.935
Data Source:  STRINGDB
Pathways (11)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
79.2
1
1
1
79.2
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
79.2
1
79.2
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acylglycerol kinase
VGNC:4251
463784
Macaque
acylglycerol kinase
694070
Mouse
MGI:1917173
69923
Rat
RGD:1562046
502749
Dog
acylglycerol kinase
VGNC:37703
482764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acylglycerol kinase
Macaque
acylglycerol kinase
Mouse
Rat
Dog
acylglycerol kinase
Publication Statistics
PubMed Score 149.95
PubMed score by year
PubTator Score 20.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title