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Tbio
AGGF1
Angiogenic factor with G patch and FHA domains 1

Protein Summary
Description
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312916
  • ENSP00000316109
  • ENSG00000164252
  • ENST00000506806
  • ENSP00000424733

Symbol
  • GPATC7
  • GPATCH7
  • VG5Q
  • VG5Q
  • GPATC7
  • GPATCH7
  • HSU84971
  • HUS84971
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.85
transcription factor perturbation
0.8
PubMedID
0.77
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.14   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.14   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999999621
p_ni:  3.79e-7
Data Source:  BioPlex
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.999998938
p_ni:  0.000001062
Data Source:  BioPlex
ZC4H2
Tbio
Novelty:  0.04969464
p_int:  0.999998175
p_ni:  0.000001825
Score:  0.534
Data Source:  BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.9999971
p_ni:  0.000002899
p_wrong:  2e-9
Score:  0.265
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999996108
p_ni:  0.000003891
Data Source:  BioPlex
RAE1
Tbio
Novelty:  0.01342883
p_int:  0.999978539
p_ni:  0.000021461
Score:  0.196
Data Source:  BioPlex,STRINGDB
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.999976104
p_ni:  0.000023896
Data Source:  BioPlex
UPF3A
Tbio
Novelty:  0.01431609
p_int:  0.999918341
p_ni:  0.000080668
p_wrong:  9.91e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999723031
p_ni:  0.000276968
p_wrong:  1e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
ENTHD1
Tdark
Novelty:  5.29427978
p_int:  0.996176119
p_ni:  0.002602882
p_wrong:  0.001220999
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
93.1
HbA1c measurement
1
2
2
84.1
BMI-adjusted waist-hip ratio
3
4
4
81
glucose measurement
2
2
2
55.8
waist-hip ratio
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
93.1
HbA1c measurement
2
84.1
BMI-adjusted waist-hip ratio
4
81
glucose measurement
2
55.8
waist-hip ratio
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
angiogenic factor with G-patch and FHA domains 1
707686
Mouse
MGI:1913799
66549
Rat
RGD:1310888
310005
Dog
angiogenic factor with G-patch and FHA domains 1
VGNC:37702
479176
Horse
angiogenic factor with G-patch and FHA domains 1
VGNC:15159
100073274
Species
Name
OMA
EggNOG
Inparanoid
Macaque
angiogenic factor with G-patch and FHA domains 1
Mouse
Rat
Dog
angiogenic factor with G-patch and FHA domains 1
Horse
angiogenic factor with G-patch and FHA domains 1
Publication Statistics
PubMed Score 49.14
PubMed score by year
PubTator Score 18.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title