Tbio AGBL4 Cytosolic carboxypeptidase 6

Protein Summary

Description

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Uniprot Accession IDs

• Q5VU57
• B3KT26
• B4DG37

Gene Name

• AGBL4

Ensembl ID

• ENST00000371839
• ENSP00000360905
• ENSG00000186094

Symbol

• CCP6
• CCP6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
phenotype	0.69
histone modification site profile	0.67
molecular function	0.67
virus perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Cytosolic Carboxypeptidase 6

Protein / ... / Metalloprotease / Cytosolic Carboxypeptidase 6

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Cytosolic Carboxypeptidase 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.44   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.44   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

TTLL4

Tbio

Family:  Enzyme

Novelty:  0.14127442

Score:  0.839

Data Source:  STRINGDB

TTLL6

Tdark

Family:  Enzyme

Novelty:  0.15224272

Score:  0.798

Data Source:  STRINGDB

TTLL1

Tdark

Family:  Enzyme

Novelty:  0.09244899

Score:  0.754

Data Source:  STRINGDB

TTLL5

Tbio

Family:  Enzyme

Novelty:  0.10212919

Score:  0.703

Data Source:  STRINGDB

CPXM2

Tbio

Family:  Enzyme

Novelty:  0.09967229

Score:  0.675

Data Source:  STRINGDB

LHPP

Tbio

Family:  Enzyme

Novelty:  0.0356879

Score:  0.647

Data Source:  STRINGDB

TTLL11

Tdark

Family:  Enzyme

Novelty:  0.72069227

Score:  0.604

Data Source:  STRINGDB

TTLL9

Tdark

Family:  Enzyme

Novelty:  0.17881456

Score:  0.603

Data Source:  STRINGDB

TTL

Tchem

Family:  Enzyme

Novelty:  0.03494724

Score:  0.598

Data Source:  STRINGDB

TTLL7

Tbio

Family:  Enzyme

Novelty:  0.14162171

Score:  0.547

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (4)

Processes (4)

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1 – 3 of 3

GO Term	Evidence	Assigned by
metallocarboxypeptidase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
tubulin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (22)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 22

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	7	6	17		92.8
smoking status measurement	EFO_0006527	1	1	1		75.6
unipolar depression	EFO_0003761	1	1	0	1	69
waist-hip ratio	EFO_0004343	2	1	2		68.3
visceral adipose tissue measurement	EFO_0004765	1	1	1		68

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 22

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	17		92.8
smoking status measurement	EFO_0006527	1		75.6
unipolar depression	EFO_0003761	0	1	69
waist-hip ratio	EFO_0004343	2		68.3
visceral adipose tissue measurement	EFO_0004765	1		68

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Carboxypeptidase
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Golgi apparatus
Hydrolase
Metal-binding
Metalloprotease

GWAS Trait Find Similar Targets

No Header	No Header
alcohol dependence
atrial fibrillation
body height
body mass index
calcium measurement
cigarettes per day measurement
heroin dependence
major depressive disorder
methamphetamine dependence
motion sickness

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ATP/GTP binding protein like 4		711073
Mouse	ATP/GTP binding protein-like 4	MGI:1918244	78933
Horse	ATP/GTP binding protein like 4 [Source:HGNC Symbol;Acc:HGNC:25892]
Opossum	ATP/GTP binding protein like 4		100619105
Zebrafish	ATP/GTP binding protein-like 4	ZDB-GENE-081104-437	550450

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ATP/GTP binding protein like 4
Mouse	ATP/GTP binding protein-like 4
Horse	ATP/GTP binding protein like 4 [Source:HGNC Symbol;Acc:HGNC:25892]
Opossum	ATP/GTP binding protein like 4
Zebrafish	ATP/GTP binding protein-like 4

Publication Statistics

PubMed Score 15.44

PubMed score by year

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PubTator Score 5.37

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (5)

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PMID	Year	Title