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Tbio
AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Protein Summary
Description
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397238
  • ENSP00000380413
  • ENSG00000133612
  • ENST00000463381
  • ENSP00000418016
  • ENST00000473312
  • ENSP00000418921
  • ENST00000622464
  • ENSP00000480655

Symbol
  • CENTG3
  • CRAG
  • AGAP-3
  • CENTG3
  • MRIP-1
  • cnt-g3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
transcription factor binding site profile
0.82
transcription factor
0.69
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.999989061
p_ni:  0.000010939
Score:  0.213
Data Source:  BioPlex,STRINGDB
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.999979025
p_ni:  0.000020975
Score:  0.188
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999975733
p_ni:  0.000024267
p_wrong:  1e-9
Data Source:  BioPlex
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
p_int:  0.999961741
p_ni:  0.000038259
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999934365
p_ni:  0.000065635
Score:  0.181
Data Source:  BioPlex,STRINGDB
KBTBD7
Tbio
Novelty:  0.4947466
p_int:  0.99967918
p_ni:  0.000320722
p_wrong:  9.8e-8
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.997330929
p_ni:  0.002650467
p_wrong:  0.000018604
Score:  0.159
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.996707916
p_ni:  0.003292084
Score:  0.214
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.985402499
p_ni:  0.014396384
p_wrong:  0.000201117
Data Source:  BioPlex
SYNGAP1
Tbio
Family:  Enzyme
Novelty:  0.00570434
Score:  0.614
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Orthology (ISO)
UniProtKB
Inferred from Sequence Orthology (ISO)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
2
3
90.6
5
1
3
1.1
89.3
appendicular lean mass
2
3
3
80.7
heel bone mineral density
2
1
2
76.6
glomerular filtration rate
2
1
2
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
3
90.6
3
1.1
89.3
appendicular lean mass
3
80.7
heel bone mineral density
2
76.6
glomerular filtration rate
2
76.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
VGNC:4249
472624
Macaque
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
714140
Mouse
MGI:2183446
213990
Rat
RGD:1310751
362300
Dog
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
VGNC:51785
100688009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Macaque
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Mouse
Rat
Dog
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Publication Statistics
PubMed Score 9.95
PubMed score by year
PubTator Score 34.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title