Tbio AGA N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

Protein Summary

Description

Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P20933
• B2R7H2
• D3DP47
• Q4W5Q2
• Q6FHN6
• Q9UCK6
• Q9UCK7
• Q9UCK8

Gene Name

• AGA

Ensembl ID

• ENST00000264595
• ENSP00000264595
• ENSG00000038002

Symbol

• GA
• AGU
• ASRG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
kinase perturbation	0.88
histone modification site profile	0.78
cellular component	0.76
transcription factor binding site profile	0.69

Protein Classes

PANTHER Classes

Protein / ... / Protease / N(4)-(beta-n-acetylglucosaminyl)-l-asparaginase

DTO Classes

Protein / Enzyme / Protease / N(4)-(beta-n-acetylglucosaminyl)-l-asparaginase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.83   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.83   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0