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Tbio
AFTPH
Aftiphilin

Protein Summary
Description
May play a role in membrane trafficking.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238855
  • ENSP00000238855
  • ENSG00000119844
  • ENST00000238856
  • ENSP00000238856
  • ENST00000409933
  • ENSP00000387071

Symbol
  • AFTH
  • Nbla10388
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.92
transcription factor binding site profile
0.91
histone modification site profile
0.85
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
AP1S2
Tbio
Novelty:  0.01413503
p_int:  0.999999999
Score:  0.934
Data Source:  BioPlex,STRINGDB
AP1S3
Tbio
Novelty:  0.14425094
p_int:  0.999999991
p_ni:  6e-9
p_wrong:  3e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999997722
p_ni:  0.000002274
p_wrong:  5e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999896248
p_ni:  0.000102818
p_wrong:  9.34e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
AP1M2
Tbio
Novelty:  0.02984354
p_int:  0.97908955
p_ni:  0.00090943
p_wrong:  0.020001019
Score:  0.889
Data Source:  BioPlex,STRINGDB
AP1G2
Tbio
Novelty:  0.17203425
Score:  0.955
Data Source:  STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
Score:  0.932
Data Source:  STRINGDB
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
Score:  0.925
Data Source:  STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.92
Data Source:  STRINGDB
AP4M1
Tbio
Novelty:  0.00142961
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
95.2
testosterone measurement
3
2
3
89.8
red blood cell distribution width
3
1
3
84.6
monocyte percentage of leukocytes
2
2
2
82
serum gamma-glutamyl transferase measurement
1
1
1
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
95.2
testosterone measurement
3
89.8
red blood cell distribution width
3
84.6
monocyte percentage of leukocytes
2
82
serum gamma-glutamyl transferase measurement
1
80.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aftiphilin
VGNC:13
459277
Macaque
aftiphilin
696100
Mouse
MGI:1923012
216549
Rat
RGD:1311920
305544
Dog
aftiphilin
VGNC:37693
474618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aftiphilin
Macaque
aftiphilin
Mouse
Rat
Dog
aftiphilin
Publication Statistics
PubMed Score 5.18
PubMed score by year
PubTator Score 3.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title