Protein Summary
May play a role in membrane trafficking.
- ENST00000238855
- ENSP00000238855
- ENSG00000119844
- ENST00000238856
- ENSP00000238856
- ENST00000409933
- ENSP00000387071
- AFTH
- Nbla10388
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
virus perturbation | 0.92 | ||
transcription factor binding site profile | 0.91 | ||
histone modification site profile | 0.85 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.18 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 95 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.18 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 95 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
AP1S3
Novelty: 0.14425094
p_int: 0.999999991
p_ni: 6e-9
p_wrong: 3e-9
Score: 0.552
Data Source: BioPlex,STRINGDB
VAPB
Novelty: 0.00542377
p_int: 0.999997722
p_ni: 0.000002274
p_wrong: 5e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
VAPA
Novelty: 0.00169209
p_int: 0.999896248
p_ni: 0.000102818
p_wrong: 9.34e-7
Score: 0.252
Data Source: BioPlex,STRINGDB
AP1M2
Novelty: 0.02984354
p_int: 0.97908955
p_ni: 0.00090943
p_wrong: 0.020001019
Score: 0.889
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 2 | 6 | 95.2 | |||||
testosterone measurement | 3 | 2 | 3 | 89.8 | |||||
red blood cell distribution width | 3 | 1 | 3 | 84.6 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 82 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 80.4 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 95.2 | |||||
testosterone measurement | 3 | 89.8 | |||||
red blood cell distribution width | 3 | 84.6 | |||||
monocyte percentage of leukocytes | 2 | 82 | |||||
serum gamma-glutamyl transferase measurement | 1 | 80.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aftiphilin | VGNC:13 | 459277 | |||||
Macaque | aftiphilin | 696100 | ||||||
Mouse | MGI:1923012 | 216549 | ||||||
Rat | RGD:1311920 | 305544 | ||||||
Dog | aftiphilin | VGNC:37693 | 474618 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aftiphilin | |||||
Macaque | aftiphilin | |||||
Mouse | ||||||
Rat | ||||||
Dog | aftiphilin | |||||
Publication Statistics
PubMed Score 5.18
PubMed score by year
PubTator Score 3.10
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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