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Tbio
AFM
Afamin

Protein Summary
Description
Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:15952736, PubMed:12463752). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407). This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226355
  • ENSP00000226355
  • ENSG00000079557

Symbol
  • ALB2
  • ALBA
  • ALF
  • ALB2
  • ALBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
protein domain
0.73
disease perturbation
0.68
kinase perturbation
0.48
tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.44   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.44   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999713071
p_ni:  0.000286929
Score:  0.172
Data Source:  BioPlex,STRINGDB
GBP1
Tbio
Novelty:  0.00634662
p_int:  0.993644635
p_ni:  0.006336536
p_wrong:  0.000018828
Score:  0.192
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.971924486
p_ni:  0.028075514
Data Source:  BioPlex
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.920474101
p_ni:  0.079525899
Score:  0.251
Data Source:  BioPlex,STRINGDB
HRG
Tbio
Novelty:  0.0027048
Score:  0.683
Data Source:  STRINGDB
CMTR2
Tbio
Family:  Enzyme
Novelty:  0.11208282
Score:  0.63
Data Source:  STRINGDB
CP
Tbio
Novelty:  0.00103285
Score:  0.565
Data Source:  STRINGDB
CPN1
Tchem
Family:  Enzyme
Novelty:  0.00331889
Score:  0.563
Data Source:  STRINGDB
HPX
Tbio
Novelty:  0.00138137
Score:  0.553
Data Source:  STRINGDB
GC
Tchem
Novelty:  0.00065382
Score:  0.547
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
1
1
86.6
serum albumin measurement
2
2
2
83.3
2
1
0
1.1
82
low density lipoprotein cholesterol measurement
1
1
1
73.6
total cholesterol measurement
1
1
1
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
86.6
serum albumin measurement
2
83.3
0
1.1
82
low density lipoprotein cholesterol measurement
1
73.6
total cholesterol measurement
1
66.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
afamin
VGNC:553
461256
Macaque
afamin
703835
Mouse
MGI:2429409
280662
Rat
RGD:628614
282708
Dog
afamin
VGNC:37691
475175
Species
Name
OMA
EggNOG
Inparanoid
Chimp
afamin
Macaque
afamin
Mouse
Rat
Dog
afamin
Publication Statistics
PubMed Score 191.44
PubMed score by year
PubTator Score 508.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title