Protein Summary
Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408). This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr ...more
- ENST00000368977
- ENSP00000357973
- ENSG00000135537
- AFG1
- LACE1
- AFG1
- LACE1
- c222389
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.68 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.68 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (24)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 7 | 8 | 5 | 7.2 | 92 | ||||
mathematical ability | 3 | 1 | 3 | 77.3 | |||||
reticulocyte measurement | 3 | 2 | 3 | 76.4 | |||||
self reported educational attainment | 3 | 2 | 2 | 7.8 | 74.7 | ||||
reticulocyte count | 2 | 2 | 2 | 72.7 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 5 | 7.2 | 92 | ||||
mathematical ability | 3 | 77.3 | |||||
reticulocyte measurement | 3 | 76.4 | |||||
self reported educational attainment | 2 | 7.8 | 74.7 | ||||
reticulocyte count | 2 | 72.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | AFG1 like ATPase | VGNC:3265 | 462920 | |||||
Macaque | AFG1 like ATPase | 700861 | ||||||
Mouse | MGI:2148801 | 215951 | ||||||
Dog | AFG1 like ATPase | VGNC:37689 | 481952 | |||||
Horse | AFG1 like ATPase | VGNC:15147 | 100066538 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | AFG1 like ATPase | |||||
Macaque | AFG1 like ATPase | |||||
Mouse | ||||||
Dog | AFG1 like ATPase | |||||
Horse | AFG1 like ATPase | |||||
Publication Statistics
PubMed Score 304.68
PubMed score by year
PubTator Score 70.92
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (7)
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0 of 0
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