AFF3
AF4/FMR2 family member 3
Protein Summary
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000317233
- ENSP00000317421
- ENSG00000144218
- ENST00000409236
- ENSP00000387207
- ENST00000409579
- ENSP00000386834
- LAF4
- LAF4
- MLLT2-like
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.99 | ||
PubMedID | 0.85 | ||
transcription factor | 0.79 | ||
cell type or tissue | 0.77 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.69 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 57 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.69 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 57 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (65)
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 0.999999958
p_ni: 3.9e-8
p_wrong: 3e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
CDK9
Family: Kinase
Novelty: 0.00210218
p_int: 0.999781253
p_ni: 5.31e-7
p_wrong: 0.000218215
Score: 0.808
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (41)
Items per page:
1 – 5 of 41
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 8 | 12 | 14 | 6.7 | 98.6 | ||||
mathematical ability | 4 | 6 | 8 | 96.9 | |||||
cognitive function measurement | 3 | 4 | 8 | 93.7 | |||||
household income | 2 | 19 | 20 | 93.4 | |||||
mean platelet volume | 2 | 3 | 3 | 92.2 | |||||
Items per page:
1 – 5 of 41
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 14 | 6.7 | 98.6 | ||||
mathematical ability | 8 | 96.9 | |||||
cognitive function measurement | 8 | 93.7 | |||||
household income | 20 | 93.4 | |||||
mean platelet volume | 3 | 92.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:106927 | 16764 | ||||||
Rat | RGD:1308527 | 363220 | ||||||
Dog | AF4/FMR2 family member 3 | VGNC:37687 | 611584 | |||||
Anole lizard | AF4/FMR2 family member 3 | 100554189 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | AF4/FMR2 family member 3 | |||||
Anole lizard | AF4/FMR2 family member 3 | |||||
Publication Statistics
PubMed Score 44.69
PubMed score by year
PubTator Score 20.17
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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