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Tbio
AFF3
AF4/FMR2 family member 3

Protein Summary
Description
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317233
  • ENSP00000317421
  • ENSG00000144218
  • ENST00000409236
  • ENSP00000387207
  • ENST00000409579
  • ENSP00000386834

Symbol
  • LAF4
  • LAF4
  • MLLT2-like
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
PubMedID
0.85
transcription factor
0.79
cell type or tissue
0.77
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.69   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.69   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999958
p_ni:  3.9e-8
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.999781253
p_ni:  5.31e-7
p_wrong:  0.000218215
Score:  0.808
Data Source:  BioPlex,STRINGDB
KIAA0319L
Tbio
Novelty:  0.02873675
Score:  0.673
Data Source:  STRINGDB
MLLT3
Tchem
Novelty:  0.00361056
Score:  0.667
Data Source:  STRINGDB
EAF1
Tbio
Novelty:  0.81120425
Score:  0.661
Data Source:  STRINGDB
TLK2
Tchem
Family:  Kinase
Novelty:  0.07082609
Score:  0.656
Data Source:  STRINGDB
ANKRD55
Tbio
Novelty:  0.09730833
Score:  0.559
Data Source:  STRINGDB
RBM39
Tbio
Novelty:  0.03319202
Score:  0.553
Data Source:  STRINGDB
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
Score:  0.548
Data Source:  STRINGDB
PTPN22
Tchem
Family:  Enzyme
Novelty:  0.00168847
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
8
12
14
6.7
98.6
mathematical ability
4
6
8
96.9
cognitive function measurement
3
4
8
93.7
household income
2
19
20
93.4
mean platelet volume
2
3
3
92.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
14
6.7
98.6
mathematical ability
8
96.9
cognitive function measurement
8
93.7
household income
20
93.4
mean platelet volume
3
92.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106927
16764
Rat
RGD:1308527
363220
Dog
AF4/FMR2 family member 3
VGNC:37687
611584
Anole lizard
AF4/FMR2 family member 3
100554189
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
AF4/FMR2 family member 3
Anole lizard
AF4/FMR2 family member 3
Publication Statistics
PubMed Score 44.69
PubMed score by year
PubTator Score 20.17
PubTator score by year
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Related Publications
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PMID
Year
Title