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Tbio
AFAP1L1
Actin filament-associated protein 1-like 1

Protein Summary
Description
May be involved in podosome and invadosome formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296721
  • ENSP00000296721
  • ENSG00000157510
  • ENST00000515000
  • ENSP00000424427
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.72
histone modification site profile
0.66
transcription factor
0.63
protein domain
0.58
PubMedID
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
p_int:  0.999406597
p_ni:  0.000252683
p_wrong:  0.00034072
Data Source:  BioPlex
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.999198293
p_ni:  0.000801111
p_wrong:  5.97e-7
Data Source:  BioPlex
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
p_int:  0.99776765
p_ni:  0.00223235
Data Source:  BioPlex
YWHAB
Tchem
Novelty:  0.00614093
p_int:  0.89587953
p_ni:  0.10412047
Data Source:  BioPlex
PTOV1
Tbio
Novelty:  0.04624884
p_int:  0.882261166
p_ni:  0.117738834
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.877182083
p_ni:  0.122817917
Data Source:  BioPlex
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.847487687
p_ni:  0.152512313
Data Source:  BioPlex
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.836214227
p_ni:  0.163785773
Data Source:  BioPlex
YWHAH
Tchem
Novelty:  0.01000071
p_int:  0.8176903
p_ni:  0.1823097
Data Source:  BioPlex
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.794253794
p_ni:  0.194438712
p_wrong:  0.011307494
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
4
82.5
forced expiratory volume
2
2
2
74
BMI-adjusted waist-hip ratio
1
1
1
59.5
mean platelet volume
1
1
1
50.6
vital capacity
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
82.5
forced expiratory volume
2
74
BMI-adjusted waist-hip ratio
1
59.5
mean platelet volume
1
50.6
vital capacity
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin filament associated protein 1 like 1
VGNC:6375
462179
Macaque
actin filament associated protein 1 like 1
709282
Mouse
MGI:2147199
106877
Rat
RGD:1311580
291565
Dog
actin filament associated protein 1 like 1
VGNC:37684
489196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin filament associated protein 1 like 1
Macaque
actin filament associated protein 1 like 1
Mouse
Rat
Dog
actin filament associated protein 1 like 1
Publication Statistics
PubMed Score 5.01
PubMed score by year
PubTator Score 3.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title