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Tbio
AFAP1
Actin filament-associated protein 1

Protein Summary
Description
Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358461
  • ENSP00000351245
  • ENSG00000196526
  • ENST00000360265
  • ENSP00000353402
  • ENST00000382543
  • ENSP00000371983
  • ENST00000420658
  • ENSP00000410689

Symbol
  • AFAP
  • AFAP
  • AFAP110
  • AFAP-110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
ligand (protein) perturbation
0.83
small molecule perturbation
0.76
hub protein
0.75
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.88   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 425   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.88   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 425   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
8
9
98.3
4
4
0
1.2
96.5
3
4
0
1.1
94.3
FEV/FEC ratio
2
2
4
67.9
mean platelet volume
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
9
98.3
0
1.2
96.5
0
1.1
94.3
FEV/FEC ratio
4
67.9
mean platelet volume
1
52.4
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
EXT2
Tbio
Family: Enzyme
Novelty: 0.00480574
p_int: 0.991335525
p_ni: 2.7e-8
p_wrong: 0.008664448
Score: 0.359
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.864
Data Source: STRINGDB
GMDS
Tbio
Family: Enzyme
Novelty: 0.00622275
Score: 0.813
Data Source: STRINGDB
MUTYH
Tbio
Family: Enzyme
Novelty: 0.00137239
Score: 0.729
Data Source: STRINGDB
SH3TC1
Tdark
Novelty: 1.6405708
Score: 0.71
Data Source: STRINGDB
NHLRC2
Tbio
Novelty: 0.18676651
Score: 0.698
Data Source: STRINGDB
CTTN
Tbio
Novelty: 0.0017962
Score: 0.698
Data Source: STRINGDB
ITIH1
Tbio
Novelty: 0.03117546
Score: 0.664
Data Source: STRINGDB
TMCO1
Tbio
Novelty: 0.04473381
Score: 0.634
Data Source: STRINGDB
ABLIM2
Tdark
Novelty: 0.23629309
Score: 0.594
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.88

PubMed score by year
PubTator Score  57.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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