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Tbio
AEN
Apoptosis-enhancing nuclease

Protein Summary
Description
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332810
  • ENSP00000331944
  • ENSG00000181026

Symbol
  • ISG20L1
  • ISG20L1
  • pp12744
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor binding site profile
0.78
small molecule perturbation
0.71
tissue sample
0.67
cellular component
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
AAMP
Tbio
Novelty:  0.0160792
p_int:  0.999987832
p_ni:  2e-9
p_wrong:  0.000012166
Score:  0.574
Data Source:  BioPlex,STRINGDB
SEMA4B
Tbio
Novelty:  0.01387522
p_int:  0.999807911
p_ni:  0.000091777
p_wrong:  0.000100312
Score:  0.689
Data Source:  BioPlex,STRINGDB
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
p_int:  0.992588367
p_ni:  0.007229668
p_wrong:  0.000181965
Score:  0.361
Data Source:  BioPlex,STRINGDB
PPID
Tchem
Family:  Enzyme
Novelty:  0.01068886
p_int:  0.943373465
p_ni:  0.056587703
p_wrong:  0.000038832
Score:  0.221
Data Source:  BioPlex,STRINGDB
CRIP2
Tbio
Novelty:  0.02211769
p_int:  0.779468296
p_ni:  0.020364082
p_wrong:  0.200167623
Score:  0.416
Data Source:  BioPlex,STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
Score:  0.728
Data Source:  STRINGDB
DFFB
Tbio
Novelty:  0.00475349
Score:  0.72
Data Source:  STRINGDB
FRMD8
Tdark
Novelty:  0.39375892
Score:  0.715
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.713
Data Source:  STRINGDB
Q9NPA5
Tbio
Family:  TF
Novelty:  0.15985218
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated transcriptional targets of TAp63 isoforms
PathwayCommons: pid
p73 transcription factor network
Name
Explore in Pharos
Explore in Source
Validated transcriptional targets of TAp63 isoforms
p73 transcription factor network
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
1
1
69.2
mean corpuscular hemoglobin concentration
1
1
1
46.9
BMI-adjusted hip circumference
2
2
2
46.8
testosterone measurement
1
1
1
38.8
Dupuytren Contracture
1
1
0
1.3
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
69.2
mean corpuscular hemoglobin concentration
1
46.9
BMI-adjusted hip circumference
2
46.8
testosterone measurement
1
38.8
Dupuytren Contracture
0
1.3
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apoptosis enhancing nuclease
VGNC:11792
453628
Mouse
MGI:1915298
68048
Rat
RGD:1305051
361594
Dog
apoptosis enhancing nuclease
VGNC:53144
488728
Horse
apoptosis enhancing nuclease [Source:HGNC Symbol;Acc:HGNC:25722]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apoptosis enhancing nuclease
Mouse
Rat
Dog
apoptosis enhancing nuclease
Horse
apoptosis enhancing nuclease [Source:HGNC Symbol;Acc:HGNC:25722]
Publication Statistics
PubMed Score 27.55
PubMed score by year
PubTator Score 2.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title