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Tbio
ADSL
Adenylosuccinate lyase

Protein Summary
Description
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342312
  • ENSP00000341429
  • ENSG00000239900
  • ENST00000623063
  • ENSP00000485525

Symbol
  • AMPS
  • ASL
  • AMPS
  • ASASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.95
protein domain
0.92
transcription factor binding site profile
0.77
histone modification site profile
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.59   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.59   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (190)
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.979870469
p_ni:  0.020129531
Score:  0.154
Data Source:  BioPlex,STRINGDB
TEKT4
Tbio
Novelty:  0.05559086
p_int:  0.979724116
p_ni:  0.020275881
p_wrong:  3e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.977194831
p_ni:  0.022805169
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.972079916
p_ni:  0.027919971
p_wrong:  1.13e-7
Score:  0.157
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.964772549
p_ni:  0.035227351
p_wrong:  1.01e-7
Data Source:  BioPlex
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.958745497
p_ni:  0.041254503
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.941307302
p_ni:  0.058692697
p_wrong:  1e-9
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.867257476
p_ni:  0.132742523
p_wrong:  1e-9
Score:  0.292
Data Source:  BioPlex,STRINGDB
TEKT2
Tbio
Novelty:  0.04607893
p_int:  0.803303672
p_ni:  0.196696328
Score:  0.19
Data Source:  BioPlex,STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
1 – 5 of 15
PDE1B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE2A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE8A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE8B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (22)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
6
7
8.5
96.6
chronotype measurement
2
2
1
1
82.4
body mass index
2
2
2
77.1
5
5
0
1.1
77
creatinine measurement
2
4
4
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
8.5
96.6
chronotype measurement
1
1
82.4
body mass index
2
77.1
0
1.1
77
creatinine measurement
4
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylosuccinate lyase
VGNC:12800
100608083
Macaque
adenylosuccinate lyase
709259
Mouse
MGI:103202
11564
Rat
RGD:1307617
315150
Horse
adenylosuccinate lyase
VGNC:49422
100070427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylosuccinate lyase
Macaque
adenylosuccinate lyase
Mouse
Rat
Horse
adenylosuccinate lyase
Publication Statistics
PubMed Score 254.59
PubMed score by year
PubTator Score 280.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title