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Tclin
ADRB3
Beta-3 adrenergic receptor

Protein Summary
Description
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345060
  • ENSP00000343782
  • ENSG00000188778

Symbol
  • ADRB3R
  • B3AR
  • BETA3AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
drug
0.85
molecular function
0.81
ligand (chemical)
0.8
chemical
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.08   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.08   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1076
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
isoprenaline
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carvedilol
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droxidopa
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norepinephrine
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epinephrine
Rendered image for epinephrine
pindolol
Rendered image for pindolol
propranolol
Rendered image for propranolol
alprenolol
Rendered image for alprenolol
levobunolol
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formoterol
Rendered image for formoterol
Protein-Protein Interactions (214)
GNB3
Tbio
Novelty:  0.0037117
Score:  0.962
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.962
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.962
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.962
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.962
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.956
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.949
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.949
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.949
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Adrenoceptors (R-HSA-390696)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Mutant Phenotype (IMP)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 3
VGNC:922
464113
Macaque
adrenoceptor beta 3
699129
Mouse
MGI:87939
11556
Rat
RGD:2061
25645
Dog
adrenoceptor beta 3
VGNC:37677
442979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 3
Macaque
adrenoceptor beta 3
Mouse
Rat
Dog
adrenoceptor beta 3
Publication Statistics
PubMed Score 837.08
PubMed score by year
PubTator Score 706.57
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title