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Tclin
ADRB2
Beta-2 adrenergic receptor

Protein Summary
Description
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological process
0.99
virus perturbation
0.99
gene perturbation
0.98
biological term
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2621.58   (req: < 5)
Gene RIFs: 654   (req: <= 3)
Antibodies: 1027   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2621.58   (req: >= 5)
Gene RIFs: 654   (req: > 3)
Antibodies: 1027   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1029
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 48
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (48)
isoprenaline
Rendered image for isoprenaline
lisuride
Rendered image for lisuride
carvedilol
Rendered image for carvedilol
droxidopa
Rendered image for droxidopa
darifenacin
Rendered image for darifenacin
dobutamine
Rendered image for dobutamine
norepinephrine
Rendered image for norepinephrine
propafenone
Rendered image for propafenone
epinephrine
Rendered image for epinephrine
pindolol
Rendered image for pindolol
Protein-Protein Interactions (391)
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.995
Data Source:  Reactome,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.991
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.991
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.981
Data Source:  Reactome,STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.981
Data Source:  Reactome,STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.975
Data Source:  Reactome,STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.969
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.969
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.969
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
3
4
95
eosinophil count
3
2
4
87
neutrophil count
3
2
3
86.5
neutrophil percentage of leukocytes
2
2
2
86.2
monocyte percentage of leukocytes
2
2
2
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
4
95
eosinophil count
4
87
neutrophil count
3
86.5
neutrophil percentage of leukocytes
2
86.2
monocyte percentage of leukocytes
2
81.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 2
VGNC:3896
471690
Macaque
adrenoceptor beta 2
710146
Mouse
MGI:87938
11555
Rat
RGD:2060
24176
Horse
adrenoceptor beta 2
VGNC:15133
100060659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor beta 2
Macaque
adrenoceptor beta 2
Mouse
Rat
Horse
adrenoceptor beta 2
Publication Statistics
PubMed Score 2621.58
PubMed score by year
PubTator Score 2895.82
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title