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Tclin
ADRA2A
Alpha-2A adrenergic receptor

Protein Summary
Description
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280155
  • ENSP00000280155
  • ENSG00000150594

Symbol
  • ADRA2R
  • ADRAR
  • ADRA2
  • ADRAR
  • ZNF32
  • ADRA2R
  • ALPHA2AAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
molecular function
0.96
ligand (chemical)
0.94
PubMedID
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.43   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.43   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 350
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (46)
clozapine
Rendered image for clozapine
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
clemastine
Rendered image for clemastine
fluphenazine
Rendered image for fluphenazine
lisuride
Rendered image for lisuride
metergoline
Rendered image for metergoline
prochlorperazine
Rendered image for prochlorperazine
carvedilol
Rendered image for carvedilol
Active Ligands (350)
Pipamazine
Rendered image for Pipamazine
CHEMBL3217984
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N-Desmethyl loperamide
Rendered image for N-Desmethyl loperamide
Alpha-Ergocryptine
Rendered image for Alpha-Ergocryptine
Ergocornine
Rendered image for Ergocornine
CHEMBL3752900
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CHEMBL193639
Rendered image for CHEMBL193639
CHEMBL363581
Rendered image for CHEMBL363581
Tamsulosin
Rendered image for Tamsulosin
Protein-Protein Interactions (330)
NPY
Tbio
Novelty:  0.00012637
Score:  0.965
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.962
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.956
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.956
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.954
Data Source:  STRINGDB
TMIGD3
Tchem
Novelty:  0.00089511
Score:  0.953
Data Source:  STRINGDB
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
Score:  0.953
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.95
Data Source:  Reactome,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.949
Data Source:  Reactome,STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Adrenaline signalling through Alpha-2 adrenergic receptor (R-HSA-392023)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline signalling through Alpha-2 adrenergic receptor
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Name
Explore in Pharos
Explore in Source
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
1
1
1
10.2
neutrophil percentage of leukocytes
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
1
10.2
neutrophil percentage of leukocytes
1
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 2A
VGNC:3798
466201
Mouse
MGI:87934
11551
Rat
RGD:2056
25083
Dog
adrenoceptor alpha 2A
VGNC:52983
486888
Pig
adrenoceptor alpha 2A
399501
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 2A
Mouse
Rat
Dog
adrenoceptor alpha 2A
Pig
adrenoceptor alpha 2A
Publication Statistics
PubMed Score 363.43
PubMed score by year
PubTator Score 331.56
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title