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Tclin
ADRA1D
Alpha-1D adrenergic receptor

Protein Summary
Description
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379453
  • ENSP00000368766
  • ENSG00000171873

Symbol
  • ADRA1A
  • DAR
  • ADRA1
  • ADRA1A
  • ADRA1R
  • ALPHA1
  • dJ779E11.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.99
chemical
0.69
disease
0.67
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.23   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.23   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 739
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 54
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (54)
clozapine
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chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
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thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
clemastine
Rendered image for clemastine
cyproheptadine
Rendered image for cyproheptadine
fluphenazine
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lisuride
Rendered image for lisuride
Protein-Protein Interactions (263)
TAC1
Tbio
Novelty:  0.00006575
Score:  0.962
Data Source:  STRINGDB
GNA13
Tbio
Novelty:  0.04149138
Score:  0.961
Data Source:  Reactome,STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.959
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.958
Data Source:  STRINGDB
AVPR1A
Tclin
Family:  GPCR
Novelty:  0.00305957
Score:  0.955
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.954
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.954
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.953
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.952
Data Source:  STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (12/13) signalling events
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (12/13) signalling events
G alpha (q) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
15
18
99.9
reticulocyte measurement
3
11
14
99.9
mean corpuscular hemoglobin concentration
1
1
1
80.7
mean reticulocyte volume
1
1
1
76.8
red blood cell distribution width
2
1
2
76
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
18
99.9
reticulocyte measurement
14
99.9
mean corpuscular hemoglobin concentration
1
80.7
mean reticulocyte volume
1
76.8
red blood cell distribution width
2
76
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 1D
VGNC:13830
469869
Mouse
MGI:106673
11550
Rat
RGD:62064
29413
Dog
adrenoceptor alpha 1D
VGNC:37674
552897
Cow
adrenoceptor alpha 1D
VGNC:25695
539543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 1D
Mouse
Rat
Dog
adrenoceptor alpha 1D
Cow
adrenoceptor alpha 1D
Publication Statistics
PubMed Score 479.23
PubMed score by year
PubTator Score 3060.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title