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Tclin
ADRA1D
Alpha-1D adrenergic receptor

Protein Summary
Description
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379453
  • ENSP00000368766
  • ENSG00000171873

Symbol
  • ADRA1A
  • DAR
  • ADRA1
  • ADRA1A
  • ADRA1R
  • ALPHA1
  • dJ779E11.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.99
chemical
0.69
disease
0.67
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 564.76   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 564.76   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 739
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 54