ADRA1D
Alpha-1D adrenergic receptor
Protein Summary
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
- ENST00000379453
- ENSP00000368766
- ENSG00000171873
- ADRA1A
- DAR
- ADRA1
- ADRA1A
- ADRA1R
- ALPHA1
- dJ779E11.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
ligand (chemical) | 0.99 | ||
chemical | 0.69 | ||
disease | 0.67 | ||
transcription factor binding site profile | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 564.76 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 564.76 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 739
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 54