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Tclin
ADRA1B
Alpha-1B adrenergic receptor

Protein Summary
Description
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306675
  • ENSP00000306662
  • ENSG00000170214

Symbol
  • ADRA1
  • ALPHA1BAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.96
biological process
0.91
gene perturbation
0.89
disease
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.25   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.25   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 637
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 30
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (30)
clozapine
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risperidone
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aripiprazole
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cyproheptadine
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quetiapine
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ketanserin
Rendered image for ketanserin
spiperone
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mianserin
Rendered image for mianserin
yohimbine
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oxymetazoline
Rendered image for oxymetazoline
Protein-Protein Interactions (260)
GNA11
Tchem
Novelty:  0.00128664
Score:  0.97
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.963
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.96
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.96
Data Source:  STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.96
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.955
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.954
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.953
Data Source:  STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.952
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (12/13) signalling events
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (12/13) signalling events
G alpha (q) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
38.2
response to red blood cell transfusion
1
1
0
16.5
27.3
alloimmunization
1
1
0
16.5
27.3
red blood cell density measurement
1
1
1
17.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
38.2
response to red blood cell transfusion
0
16.5
27.3
alloimmunization
0
16.5
27.3
red blood cell density measurement
1
17.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 1B
VGNC:11727
736934
Mouse
MGI:104774
11548
Rat
RGD:2054
24173
Dog
adrenoceptor alpha 1B
VGNC:37673
403962
Horse
adrenoceptor alpha 1B
VGNC:15132
100071055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 1B
Mouse
Rat
Dog
adrenoceptor alpha 1B
Horse
adrenoceptor alpha 1B
Publication Statistics
PubMed Score 256.25
PubMed score by year
PubTator Score 134.20
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title