You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
ADRA1A
Alpha-1A adrenergic receptor

Protein Summary
Description
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276393
  • ENSP00000276393
  • ENSG00000120907
  • ENST00000354550
  • ENSP00000346557
  • ENST00000380572
  • ENSP00000369946
  • ENST00000380573
  • ENSP00000369947
  • ENST00000380582
  • ENSP00000369956
  • ENST00000380586
  • ENSP00000369960
  • ENST00000519096
  • ENSP00000431073
  • ENST00000521711
  • ENSP00000430414

Symbol
  • ADRA1C
  • ADRA1C
  • ADRA1L1
  • ALPHA1AAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.99
biological process
0.97
chemical
0.85
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1202
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 43