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Tbio
ADPGK
ADP-dependent glucokinase

Protein Summary
Description
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311669
  • ENSP00000312250
  • ENSG00000159322
  • ENST00000456471
  • ENSP00000397694
  • ENST00000562823
  • ENSP00000454367
  • ENST00000567941
  • ENSP00000458102
  • ENST00000569517
  • ENSP00000454304

Symbol
  • ADP-GK
  • 2610017G09Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
virus perturbation
0.95
disease perturbation
0.9
cell type or tissue
0.81
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.02   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.02   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
PLTP
Tbio
Novelty:  0.00267612
p_int:  0.995348197
p_ni:  0.004651803
Score:  0.241
Data Source:  BioPlex,STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
p_int:  0.995220688
p_ni:  0.004779312
Score:  0.449
Data Source:  BioPlex,STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.992383226
p_ni:  0.007616753
p_wrong:  2.1e-8
Data Source:  BioPlex
GALNT7
Tbio
Family:  Enzyme
Novelty:  0.05328171
p_int:  0.986124898
p_ni:  0.013875102
Score:  0.522
Data Source:  BioPlex,STRINGDB
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
p_int:  0.983099409
p_ni:  0.016900591
Score:  0.665
Data Source:  BioPlex,STRINGDB
TOR1B
Tbio
Novelty:  0.00611826
p_int:  0.981536764
p_ni:  0.018463236
Score:  0.311
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.98038304
p_ni:  0.01961696
Data Source:  BioPlex
MGAT1
Tchem
Family:  Enzyme
Novelty:  0.01024931
p_int:  0.968152869
p_ni:  0.031847131
Score:  0.26
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.960257738
p_ni:  0.039742262
Score:  0.328
Data Source:  BioPlex,STRINGDB
EPHB4
Tchem
Family:  Kinase
Novelty:  0.00422975
p_int:  0.949196861
p_ni:  0.050803137
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
5
7
88.6
body height
1
1
1
60.5
grip strength measurement
1
1
1
33.1
waist-hip ratio
1
1
1
33.1
triglyceride measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
88.6
body height
1
60.5
grip strength measurement
1
33.1
waist-hip ratio
1
33.1
triglyceride measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP dependent glucokinase
VGNC:11790
748791
Macaque
ADP dependent glucokinase
699257
Mouse
MGI:1919391
72141
Rat
RGD:1306103
315722
Dog
ADP dependent glucokinase
VGNC:37669
478360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP dependent glucokinase
Macaque
ADP dependent glucokinase
Mouse
Rat
Dog
ADP dependent glucokinase
Publication Statistics
PubMed Score 20.02
PubMed score by year
PubTator Score 7.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title