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Tchem
ADORA3
Adenosine receptor A3

Protein Summary
Description
Isoform 2: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299). Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186). This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobuli ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241356
  • ENSP00000241356
  • ENSG00000282608

Symbol
  • A3AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.95
gene perturbation
0.65
chemical
0.64
disease
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.81   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.81   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1975
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 23
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (23)
ketanserin
Rendered image for ketanserin
yohimbine
Rendered image for yohimbine
imipramine
Rendered image for imipramine
diazepam
Rendered image for diazepam
choline theophyllinate
no chemical structure image available
bufylline
no chemical structure image available
nicardipine
Rendered image for nicardipine
mepyramine
Rendered image for mepyramine
dexniguldipine
Rendered image for dexniguldipine
kainic acid
Rendered image for kainic acid
Protein-Protein Interactions (313)
TBC1D9B
Tdark
Novelty:  0.66719861
p_int:  0.99930851
p_ni:  0.00069149
Score:  0.227
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.969060768
p_ni:  0.030932701
p_wrong:  0.000006532
Score:  0.178
Data Source:  BioPlex,STRINGDB
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.967365865
p_ni:  0.015772435
p_wrong:  0.016861699
Score:  0.208
Data Source:  BioPlex,STRINGDB
IPO9
Tbio
Novelty:  0.03978028
p_int:  0.931299544
p_ni:  0.068700456
Score:  0.193
Data Source:  BioPlex,STRINGDB
CAND2
Tbio
Novelty:  0.08940552
p_int:  0.878132634
p_ni:  0.121867366
Score:  0.165
Data Source:  BioPlex,STRINGDB
IPO11
Tbio
Novelty:  0.09553616
p_int:  0.76819606
p_ni:  0.231803898
p_wrong:  4.1e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.968
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.966
Data Source:  STRINGDB
P2RY4
Tchem
Family:  GPCR
Novelty:  0.00903213
Score:  0.956
Data Source:  STRINGDB
P2RY14
Tchem
Family:  GPCR
Novelty:  0.0135462
Score:  0.955
Data Source:  STRINGDB
Pathways (22)
Adenosine P1 receptors (R-HSA-417973)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adenosine P1 receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Adenosine P1 receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
38.2
energy intake measurement
1
1
0
145
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
38.2
energy intake measurement
0
145
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104847
11542
Dog
adenosine A3 receptor
VGNC:37668
403805
Cow
adenosine A3 receptor
780806
Pig
transmembrane and immunoglobulin domain containing 3 isoform 3 [Source:RefSeq peptide;Acc:NP_001289700]
Chicken
adenosine A3 receptor
CGNC:48977
373956
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
adenosine A3 receptor
Cow
adenosine A3 receptor
Pig
transmembrane and immunoglobulin domain containing 3 isoform 3 [Source:RefSeq peptide;Acc:NP_001289700]
Chicken
adenosine A3 receptor
Publication Statistics
PubMed Score 1461.81
PubMed score by year
PubTator Score 255.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title