Protein Summary
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000309502
- ENSP00000308549
- ENSG00000163485
- ENST00000337894
- ENSP00000338435
- ENST00000367235
- ENSP00000356204
- ENST00000367236
- ENSP00000356205
- ENST00000640524
- ENSP00000491900
- RDC7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
ligand (chemical) | 1 | ||
molecular function | 0.96 | ||
transcription factor perturbation | 0.91 | ||
PubMedID | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2398.98 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 455 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2398.98 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 455 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1631
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (7)
Active Ligands (1631)
Protein-Protein Interactions (316)
Nearest Tclin Targets
Pathways (32)
Reactome (8)
KEGG (7)
PathwayCommons (13)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adenosine P1 receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adenosine P1 receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (70)
Functions (8)
Components (13)
Processes (49)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 0 | 1.1 | 92.2 | |||||
YKL40 measurement | 2 | 2 | 2 | 90 | |||||
childhood onset asthma | 2 | 1 | 0 | 1.1 | 73.5 | ||||
5 | 5 | 0 | 1 | 70.9 | |||||
systolic blood pressure | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 92.2 | |||||
YKL40 measurement | 2 | 90 | |||||
childhood onset asthma | 0 | 1.1 | 73.5 | ||||
0 | 1 | 70.9 | |||||
systolic blood pressure | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adenosine A1 receptor | VGNC:10535 | 457638 | |||||
Macaque | adenosine A1 receptor | 703638 | ||||||
Mouse | MGI:99401 | 11539 | ||||||
Rat | RGD:2048 | 29290 | ||||||
Dog | adenosine A1 receptor | VGNC:37665 | 403961 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adenosine A1 receptor | |||||
Macaque | adenosine A1 receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | adenosine A1 receptor | |||||
Publication Statistics
PubMed Score 2398.98
PubMed score by year
PubTator Score 190.30
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (123)
GeneRif Annotations (82)
Items per page:
0 of 0
PMID | Year | Title |
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