Protein Summary
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000309502
- ENSP00000308549
- ENSG00000163485
- ENST00000337894
- ENSP00000338435
- ENST00000367235
- ENSP00000356204
- ENST00000367236
- ENSP00000356205
- ENST00000640524
- ENSP00000491900
- RDC7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
ligand (chemical) | 1 | ||
molecular function | 0.96 | ||
transcription factor perturbation | 0.91 | ||
PubMedID | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2575.89 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 455 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2575.89 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 455 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1660
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7