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Tclin
ADORA1
Adenosine receptor A1

Protein Summary
Description
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309502
  • ENSP00000308549
  • ENSG00000163485
  • ENST00000337894
  • ENSP00000338435
  • ENST00000367235
  • ENSP00000356204
  • ENST00000367236
  • ENSP00000356205
  • ENST00000640524
  • ENSP00000491900

Symbol
  • RDC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (chemical)
1
molecular function
0.96
transcription factor perturbation
0.91
PubMedID
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2575.89   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2575.89   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1660
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7